P02538: Keratin, type II cytoskeletal 6A

General Information

Protein names	- Keratin, type II cytoskeletal 6A - Cytokeratin-6A - CK-6A - Cytokeratin-6D - CK-6D - Keratin-6A - K6A - Type-II keratin Kb6 - Hom s 5
Gene names	KRT6A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02538

3 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSVSVSR SRGSGGLGGA CGGAGFGSRS
        70         80         90        100        110        120
LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF GFGGGAGIGF GLGGGAGLAG
       130        140        150        160        170        180
GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL QIDPTIQRVR AEEREQIKTL NNKFASFIDK
       190        200        210        220        230        240
VRFLEQQNKV LETKWTLLQE QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR
       250        260        270        280        290        300
GMQDLVEDFK NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA
       310        320        330        340        350        360
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA EAESWYQTKY
       370        380        390        400        410        420
EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK QCANLQAAIA DAEQRGEMAL
       430        440        450        460        470        480
KDAKNKLEGL EDALQKAKQD LARLLKEYQE LMNVKLALDV EIATYRKLLE GEECRLNGEG
       490        500        510        520        530        540
VGQVNISVVQ STVSSGYGGA SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRAIGGGLS
       550        560
SVGGGSSTIK YTTTSSSSRK SYKH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02538-2-unknown	MASTST...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02538-2-Acetylation	ASTSTT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02538-2-Acetylation	ASTSTT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P02538-2-Acetylation	ASTSTT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P02538-185-unknown	EQQNKV...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17028
P02538-185-unknown	EQQNKV...	185		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18370

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVRFLE	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17028
...KVRFLE	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18370
...KSYKH	564	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	184	RFLE.\|.EQQN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	184	RFLE.\|.EQQN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)