Q53GQ0: Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305}
Protein names | - Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305} - 1.1.1.330 {ECO:0000269|PubMed:12482854} - 17-beta-hydroxysteroid dehydrogenase 12 {ECO:0000303|PubMed:16166196} - 17-beta-HSD 12 {ECO:0000303|PubMed:16166196} - 3-ketoacyl-CoA reductase {ECO:0000303|PubMed:12482854} - KAR {ECO:0000303|PubMed:12482854} - Estradiol 17-beta-dehydrogenase 12 {ECO:0000303|PubMed:16166196} - 1.1.1.62 {ECO:0000269|PubMed:16166196} - Short chain dehydrogenase/reductase family 12C member 1 |
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Gene names | HSD17B12 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q53GQ0 |
2
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MESALPAAGF LYWVGAGTVA YLALRISYSL FTALRVWGVG NEAGVGPGLG EWAVVTGSTD
70 80 90 100 110 120
GIGKSYAEEL AKHGMKVVLI SRSKDKLDQV SSEIKEKFKV ETRTIAVDFA SEDIYDKIKT
130 140 150 160 170 180
GLAGLEIGIL VNNVGMSYEY PEYFLDVPDL DNVIKKMINI NILSVCKMTQ LVLPGMVERS
190 200 210 220 230 240
KGAILNISSG SGMLPVPLLT IYSATKTFVD FFSQCLHEEY RSKGVFVQSV LPYFVATKLA
250 260 270 280 290 300
KIRKPTLDKP SPETFVKSAI KTVGLQSRTN GYLIHALMGS IISNLPSWIY LKIVMNMNKS
310
TRAHYLKKTK KN
Isoforms
- Isoform 2 of Very-long-chain 3-oxoacyl-CoA reductaseSequence View
10 20 30 40 50 60
MESALPAAGF LYWVGAGTVA YLALRISYSL FTALRVWGVG NEAGVGPGLG EWAVVTGSTD
70 80 90 100 110 120
GIGKSYAEEL AKHGMKVVLI SRSKDKLDQV SSEIKEKFKV ETRTIAVDFA SEDIYDKIKT
130 140 150 160 170 180
GLAGLEIGIL VNNVGMSYEY PEYFLDVPDL DNVIKKMINI NILSVCKMTQ LVLPGMVERS
190 200 210 220 230 240
KGAILNISSG SGMLPVPLLT IYSATKTFVD FFSQCLHEEY RSKGVFVQSV LPYFVATKLA
250 260 270 280 290 300
KIRKPTLDKP SPETFVKSAI KTVGLQSRTN GYLIHALMGS IISNLPSWIY LKIVMNMNKS
310
TRAHYLKKTK KN
Protein Neighborhood
Domains & Features
2 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q53GQ0-1-unknown | MESALP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q53GQ0-248-unknown | DKPSPE... | 248 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18006 | |||
Q53GQ0-248-unknown | DKPSPE... | 248 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19611 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IYSATK | 205 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000436582 | |||
...RKPTLD | 247 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18006 | |||
...RKPTLD | 247 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19611 | |||
...KTKKN | 312 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1A_HUMAN | 247 | PTLD.|.DKPS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1B_HUMAN | 247 | PTLD.|.DKPS | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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