Q53GQ0: Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305}

General Information

Protein names	- Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305} - 1.1.1.330 {ECO:0000269\|PubMed:12482854} - 17-beta-hydroxysteroid dehydrogenase 12 {ECO:0000303\|PubMed:16166196} - 17-beta-HSD 12 {ECO:0000303\|PubMed:16166196} - 3-ketoacyl-CoA reductase {ECO:0000303\|PubMed:12482854} - KAR {ECO:0000303\|PubMed:12482854} - Estradiol 17-beta-dehydrogenase 12 {ECO:0000303\|PubMed:16166196} - 1.1.1.62 {ECO:0000269\|PubMed:16166196} - Short chain dehydrogenase/reductase family 12C member 1
Gene names	HSD17B12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53GQ0

2 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESALPAAGF LYWVGAGTVA YLALRISYSL FTALRVWGVG NEAGVGPGLG EWAVVTGSTD
        70         80         90        100        110        120
GIGKSYAEEL AKHGMKVVLI SRSKDKLDQV SSEIKEKFKV ETRTIAVDFA SEDIYDKIKT
       130        140        150        160        170        180
GLAGLEIGIL VNNVGMSYEY PEYFLDVPDL DNVIKKMINI NILSVCKMTQ LVLPGMVERS
       190        200        210        220        230        240
KGAILNISSG SGMLPVPLLT IYSATKTFVD FFSQCLHEEY RSKGVFVQSV LPYFVATKLA
       250        260        270        280        290        300
KIRKPTLDKP SPETFVKSAI KTVGLQSRTN GYLIHALMGS IISNLPSWIY LKIVMNMNKS
       310
TRAHYLKKTK KN

Isoforms

- Isoform 2 of Very-long-chain 3-oxoacyl-CoA reductase

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q53GQ0-1-unknown	MESALP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q53GQ0-248-unknown	DKPSPE...	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18006
Q53GQ0-248-unknown	DKPSPE...	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19611

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IYSATK	205	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436582
...RKPTLD	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18006
...RKPTLD	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19611
...KTKKN	312	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	247	PTLD.\|.DKPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	247	PTLD.\|.DKPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)