P35241: Radixin

General Information

Protein names	- Radixin
Gene names	RDX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35241

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Radixin - Isoform 3 of Radixin - Isoform 4 of Radixin - Isoform 5 of Radixin

Sequence View

        10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
        70         80         90        100        110        120
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
       130        140        150        160        170        180
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
       190        200        210        220        230        240
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK
       370        380        390        400        410        420
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
       430        440        450        460        470        480
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP
       490        500        510        520        530        540
PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD
       550        560        570        580
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM         10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
        70         80         90        100        110        120
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
       130        140        150        160        170        180
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
       190        200        210        220        230        240
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK
       370        380        390        400        410        420
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
       430        440        450        460        470        480
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP
       490        500        510        520        530        540
PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD
       550        560        570        580
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM         10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
        70         80         90        100        110        120
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
       130        140        150        160        170        180
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
       190        200        210        220        230        240
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK
       370        380        390        400        410        420
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
       430        440        450        460        470        480
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP
       490        500        510        520        530        540
PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD
       550        560        570        580
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM         10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
        70         80         90        100        110        120
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
       130        140        150        160        170        180
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
       190        200        210        220        230        240
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK
       370        380        390        400        410        420
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
       430        440        450        460        470        480
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP
       490        500        510        520        530        540
PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD
       550        560        570        580
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35241-1-unknown	MPKPIN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P35241-1-unknown	MPKPIN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86912
P35241-1-unknown	MPKPIN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86914
P35241-17-unknown	EFAIQP...	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19064
P35241-17-unknown	EFAIQP...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136635
P35241-348-unknown	MERLKQ...	348	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86911
P35241-348-unknown	MERLKQ...	348	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103115
P35241-348-unknown	MERLKQ...	348	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103114

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MDAELE	16	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19064
...EFEAM	583		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EFEAM	583	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EFEAM	583	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82531
...EFEAM	583		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EFEAM	583	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt92801
...EFEAM	583	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt92802
...EFEAM	583	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt92800

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	16	AELE.\|.EFAI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)