Q13838: Spliceosome RNA helicase DDX39B

General Information

Protein names	- Spliceosome RNA helicase DDX39B - 3.6.4.13 - 56 kDa U2AF65-associated protein - ATP-dependent RNA helicase p47 - DEAD box protein UAP56 - HLA-B-associated transcript 1 protein
Gene names	DDX39B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13838

11 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF LLKPELLRAI
        70         80         90        100        110        120
VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV LATLQQLEPV TGQVSVLVMC
       130        140        150        160        170        180
HTRELAFQIS KEYERFSKYM PNVKVAVFFG GLSIKKDEEV LKKNCPHIVV GTPGRILALA
       190        200        210        220        230        240
RNKSLNLKHI KHFILDECDK MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LSKEIRPVCR
       250        260        270        280        290        300
KFMQDPMEIF VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC
       310        320        330        340        350        360
IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG MDIERVNIAF
       370        380        390        400        410        420
NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL NDVQDRFEVN ISELPDEIDI

SSYIEQTR

Isoforms

- Isoform 2 of Spliceosome RNA helicase DDX39B

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13838-1-unknown	MAENDV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73379
Q13838-2-unknown	MAENDV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13838-2-Acetylation	AENDVD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13838-2-Acetylation	AENDVD...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13838-2-Acetylation	AENDVD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111330
Q13838-16-unknown	DEVETA...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19486
Q13838-16-unknown	DEVETA...	16		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136574
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13838-20-	TAAGGD...	20			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13838-20-unknown	TAAGGD...	20			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13838-20-unknown	TAAGGD...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162260
Q13838-23-unknown	GGDGAE...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19488
Q13838-23-unknown	GGDGAE...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137056
Q13838-34-	DVKGSY...	34			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13838-34-	DVKGSY...	34			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13838-34-	DVKGSY...	34			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q13838-34-unknown	DVKGSY...	34		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165479
Q13838-49-unknown	DFLLKP...	49		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10277
Q13838-49-unknown	DFLLKP...	49		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139053
Q13838-67-unknown	HPSEVQ...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6366
Q13838-67-unknown	HPSEVQ...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140466

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDYEDD	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19486
...VETAAG	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19488
...VETAAG	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119910
...SSGFRD	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10277
...SSGFRD	48	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122124
...DCGFEH	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6366
...DCGFEH	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123593
...IEQTR	428	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IEQTR	428	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68997

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	15	YEDD.\|.DEVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	22	TAAG.\|.GGDG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	48	GFRD.\|.DFLL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	66	GFEH.\|.HPSE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)