Q92817: Envoplakin

General Information

Protein names	- Envoplakin - 210 kDa cornified envelope precursor protein - 210 kDa paraneoplastic pemphigus antigen - p210
Gene names	EVPL
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92817

4 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA DQVERDILET
        70         80         90        100        110        120
QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD VDKARRLKHP QAEEIEKDIK
       130        140        150        160        170        180
QLHERVTQEC AEYRALYEKM VLPPDVGPRV DWARVLEQKQ KQVCAGQYGP GMAELEQQIA
       190        200        210        220        230        240
EHNILQKEID AYGQQLRSLV GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS
       250        260        270        280        290        300
ALAEQQRRIL QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA
       310        320        330        340        350        360
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA KLNSNLDAKY
       370        380        390        400        410        420
SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR DVAPLPQRRN PPQQPLHVDS
       430        440        450        460        470        480
ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV QGPGGETKRA PAACFCIPAP DPDAVARASR
       490        500        510        520        530        540
LASELQALKQ KLATVQSRLK ASAVESLRPS QQAPSGSDLA NPQAQKLLTQ MTRLDGDLGQ
       550        560        570        580        590        600
IERQVLAWAR APLSRPTPLE DLEGRIHSHE GTAQRLQSLG TEKETAQKEC EAFLSTRPVG
       610        620        630        640        650        660
PAALQLPVAL NSVKNKFSDV QVLCSLYGEK AKAALDLERQ IQDADRVIRG FEATLVQEAP
       670        680        690        700        710        720
IPAEPGALQE RVSELQRQRR ELLEQQTCVL RLHRALKASE HACAALQNNF QEFCQDLPRQ
       730        740        750        760        770        780
QRQVRALTDR YHAVGDQLDL REKVVQDAAL TYQQFKNCKD NLSSWLEHLP RSQVRPSDGP
       790        800        810        820        830        840
SQIAYKLQAQ KRLTQEIQSR ERDRATASHL SQALQAALQD YELQADTYRC SLEPTLAVSA
       850        860        870        880        890        900
PKRPRVAPLQ ESIQAQEKNL AKAYTEVAAA QQQLLQQLEF ARKMLEKKEL SEDIRRTHDA
       910        920        930        940        950        960
KQGSESPAQA GRESEALKAQ LEEERKRVAR VQHELEAQRS QLLQLRTQRP LERLEEKEVV
       970        980        990       1000       1010       1020
EFYRDPQLEG SLSRVKAQVE EEGKRRAGLQ ADLEVAAQKV VQLESKRKTM QPHLLTKEVT
      1030       1040       1050       1060       1070       1080
QVERDPGLDS QAAQLRIQIQ QLRGEDAVIS ARLEGLKKEL LALEKREVDV KEKVVVKEVV
      1090       1100       1110       1120       1130       1140
KVEKNLEMVK AAQALRLQME EDAARRKQAE EAVAKLQARI EDLERAISSV EPKVIVKEVK
      1150       1160       1170       1180       1190       1200
KVEQDPGLLQ ESSRLRSLLE EERTKNATLA RELSDLHSKY SVVEKQRPKV QLQERVHEIF
      1210       1220       1230       1240       1250       1260
QVDPETEQEI TRLKAKLQEM AGKRSGVEKE VEKLLPDLEV LRAQKPTVEY KEVTQEVVRH
      1270       1280       1290       1300       1310       1320
ERSPEVLREI DRLKAQLNEL VNSHGRSQEQ LIRLQGERDE WRRERAKVET KTVSKEVVRH
      1330       1340       1350       1360       1370       1380
EKDPVLEKEA ERLRQEVREA AQKRRAAEDA VYELQSKRLL LERRKPEEKV VVQEVVVTQK
      1390       1400       1410       1420       1430       1440
DPKLREEHSR LSGSLDEEVG RRRQLELEVQ QLRAGVEEQE GLLSFQEDRS KKLAVERELR
      1450       1460       1470       1480       1490       1500
QLTLRIQELE KRPPTVQEKI IMEEVVKLEK DPDLEKSTEA LRWDLDQEKT QVTELNRECK
      1510       1520       1530       1540       1550       1560
NLQVQIDVLQ KAKSQEKTIY KEVIRVQKDR VLEDERARVW EMLNRERTAR QAREEEARRL
      1570       1580       1590       1600       1610       1620
RERIDRAETL GRTWSREESE LQRARDQADQ ECGRLQQELR ALERQKQQQT LQLQEESKLL
      1630       1640       1650       1660       1670       1680
SQKTESERQK AAQRGQELSR LEAAILREKD QIYEKERTLR DLHAKVSREE LSQETQTRET
      1690       1700       1710       1720       1730       1740
NLSTKISILE PETGKDMSPY EAYKRGIIDR GQYLQLQELE CDWEEVTTSG PCGEESVLLD
      1750       1760       1770       1780       1790       1800
RKSGKQYSIE AALRCRRISK EEYHLYKDGH LPISEFALLV AGETKPSSSL SIGSIISKSP
      1810       1820       1830       1840       1850       1860
LASPAPQSTS FFSPSFSLGL GDDSFPIAGI YDTTTDNKCS IKTAVAKNML DPITGQKLLE
      1870       1880       1890       1900       1910       1920
AQAATGGIVD LLSRERYSVH KAMERGLIEN TSTQRLLNAQ KAFTGIEDPV TKKRLSVGEA
      1930       1940       1950       1960       1970       1980
VQKGWMPRES VLPHLQVQHL TGGLIDPKRT GRIPIQQALL SGMISEELAQ LLQDESSYEK
      1990       2000       2010       2020       2030
DLTDPISKER LSYKEAMGRC RKDPLSGLLL LPAALEGYRC YRSASPTVPR SLR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92817-1-unknown	MFKGLS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92817-1-acetylation	MFKGLS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q92817-992-unknown	DLEVAA...	992		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19723
Q92817-992-unknown	DLEVAA...	992		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18062
Q92817-1922-unknown	QKGWMP...	1922		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467717

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AGLQAD	991	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19723
...AGLQAD	991	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18062
...PRSLR	2033	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	991	LQAD.\|.DLEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	991	LQAD.\|.DLEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)