Q99459: Cell division cycle 5-like protein

General Information

Protein names	- Cell division cycle 5-like protein - Cdc5-like protein - Pombe cdc5-related protein
Gene names	CDC5L
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99459

11 N-termini

9 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK
        70         80         90        100        110        120
TEWSREEEEK LLHLAKLMPT QWRTIAPIIG RTAAQCLEHY EFLLDKAAQR DNEEETTDDP
       130        140        150        160        170        180
RKLKPGEIDP NPETKPARPD PIDMDEDELE MLSEARARLA NTQGKKAKRK AREKQLEEAR
       190        200        210        220        230        240
RLAALQKRRE LRAAGIEIQK KRKRKRGVDY NAEIPFEKKP ALGFYDTSEE NYQALDADFR
       250        260        270        280        290        300
KLRQQDLDGE LRSEKEGRDR KKDKQHLKRK KESDLPSAIL QTSGVSEFTK KRSKLVLPAP
       310        320        330        340        350        360
QISDAELQEV VKVGQASEIA RQTAEESGIT NSASSTLLSE YNVTNNSVAL RTPRTPASQD
       370        380        390        400        410        420
RILQEAQNLM ALTNVDTPLK GGLNTPLHES DFSGVTPQRQ VVQTPNTVLS TPFRTPSNGA
       430        440        450        460        470        480
EGLTPRSGTT PKPVINSTPG RTPLRDKLNI NPEDGMADYS DPSYVKQMER ESREHLRLGL
       490        500        510        520        530        540
LGLPAPKNDF EIVLPENAEK ELEEREIDDT YIEDAADVDA RKQAIRDAER VKEMKRMHKA
       550        560        570        580        590        600
VQKDLPRPSE VNETILRPLN VEPPLTDLQK SEELIKKEMI TMLHYDLLHH PYEPSGNKKG
       610        620        630        640        650        660
KTVGFGTNNS EHITYLEHNP YEKFSKEELK KAQDVLVQEM EVVKQGMSHG ELSSEAYNQV
       670        680        690        700        710        720
WEECYSQVLY LPGQSRYTRA NLASKKDRIE SLEKRLEINR GHMTTEAKRA AKMEKKMKIL
       730        740        750        760        770        780
LGGYQSRAMG LMKQLNDLWD QIEQAHLELR TFEELKKHED SAIPRRLECL KEDVQRQQER
       790        800
EKELQHRYAD LLLEKETLKS KF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

11 N-termini - 9 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99459-1-unknown	MPRIMI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99459-146-unknown	EDELEM...	146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13129
Q99459-222-unknown	LGFYDT...	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14885
Q99459-274-unknown	DLPSAI...	274	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19744
Q99459-274-unknown	DLPSAI...	274	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18080
Q99459-283-unknown	SGVSEF...	283	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13130
Q99459-302-unknown	ISDAEL...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14886
Q99459-305-unknown	AELQEV...	305	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13131
Q99459-373-unknown	TNVDTP...	373	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14887
Q99459-392-	FSGVTP...	392		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99459-392-	FSGVTP...	392		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q99459-392-	FSGVTP...	392		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q99459-392-	FSGVTP...	392		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99459-392-	FSGVTP...	392		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q99459-392-unknown	FSGVTP...	392		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q99459-459-unknown	YSDPSY...	459	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13132

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIDMDE	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13129
...EKKPAL	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14885
...RKKESD	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19744
...RKKESD	273	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18080
...AILQTS	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13130
...LPAPQI	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14886
...PQISDA	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13131
...NLMALT	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14887
...DGMADY	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13132
...LKSKF	802	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	145	DMDE.\|.EDEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	221	KPAL.\|.LGFY	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	273	KESD.\|.DLPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	273	KESD.\|.DLPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	282	LQTS.\|.SGVS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	301	APQI.\|.ISDA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	304	ISDA.\|.AELQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	372	MALT.\|.TNVD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	458	MADY.\|.YSDP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)