P50990: T-complex protein 1 subunit theta

General Information

Protein names	- T-complex protein 1 subunit theta - TCP-1-theta - CCT-theta - Chaperonin containing T-complex polypeptide 1 subunit 8 - Renal carcinoma antigen NY-REN-15
Gene names	CCT8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50990

17 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of T-complex protein 1 subunit theta - Isoform 3 of T-complex protein 1 subunit theta

Sequence View

        10         20         30         40         50         60
MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINHL
        70         80         90        100        110        120
EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR
       130        140        150        160        170        180
IGLSVSEVIE GYEIACRKAH EILPNLVCCS AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA
       190        200        210        220        230        240
KLIAQACVSI FPDSGHFNVD NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA
       250        260        270        280        290        300
VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM
       310        320        330        340        350        360
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV YLSEVGDTQV
       370        380        390        400        410        420
VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA
       430        440        450        460        470        480
KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYAV HQEGNKNVGL
       490        500        510        520        530        540
DIEAEVPAVK DMLEAGILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK

DWDDDQND         10         20         30         40         50         60
MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINHL
        70         80         90        100        110        120
EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR
       130        140        150        160        170        180
IGLSVSEVIE GYEIACRKAH EILPNLVCCS AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA
       190        200        210        220        230        240
KLIAQACVSI FPDSGHFNVD NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA
       250        260        270        280        290        300
VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM
       310        320        330        340        350        360
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV YLSEVGDTQV
       370        380        390        400        410        420
VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA
       430        440        450        460        470        480
KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYAV HQEGNKNVGL
       490        500        510        520        530        540
DIEAEVPAVK DMLEAGILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK

DWDDDQND

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50990-2-unknown	MALHVP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50990-2-Acetylation	ALHVPK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50990-23-unknown	SGLEEA...	23		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182758
P50990-23-	SGLEEA...	23			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P50990-69-unknown	AATILR...	69		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177822
P50990-69-	AATILR...	69			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50990-267-unknown	NFSKGE...	267		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177819
P50990-267-unknown	NFSKGE...	267		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177820
P50990-267-	NFSKGE...	267			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P50990-282-	AIADTG...	282			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50990-282-unknown	AIADTG...	282		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167369
P50990-282-unknown	AIADTG...	282		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167370
P50990-285-unknown	DTGANV...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17690
P50990-285-unknown	DTGANV...	285		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19171
P50990-285-unknown	DTGANV...	285		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147044
P50990-285-unknown	DTGANV...	285		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149011
P50990-369-unknown	DGAIST...	369		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19174
P50990-369-unknown	DGAIST...	369		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149776
P50990-369-unknown	DGAIST...	369		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150947
P50990-379-	GSTDNL...	379			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50990-379-	GSTDNL...	379			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P50990-379-unknown	GSTDNL...	379		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170781
P50990-379-unknown	GSTDNL...	379		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170782
P50990-380-	STDNLM...	380			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50990-380-	STDNLM...	380			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P50990-380-unknown	STDNLM...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170784
P50990-380-unknown	STDNLM...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170785
P50990-480-unknown	LDIEAE...	480		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5953
P50990-480-unknown	LDIEAE...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152103
P50990-480-unknown	LDIEAE...	480		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152921

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKAIAD	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17690
...VKAIAD	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19171
...VKAIAD	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130377
...VKAIAD	284	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132394
...KHEKED	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19174
...KHEKED	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133167
...KHEKED	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134349
...STIVLR	377	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416832
...STIVLR	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112187
...STIVLR	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112186
...NKNVGL	479	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5953
...NKNVGL	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135512
...NKNVGL	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136347
...DDQND	548	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DDQND	548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87376
...DDQND	548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87375

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	284	AIAD.\|.DTGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	284	AIAD.\|.DTGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	368	EKED.\|.DGAI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	479	NVGL.\|.LDIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)