Q9Y624: Junctional adhesion molecule A

General Information

Protein names	- Junctional adhesion molecule A - JAM-A - Junctional adhesion molecule 1 - JAM-1 - Platelet F11 receptor - Platelet adhesion molecule 1 - PAM-1 - CD321
Gene names	F11R
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y624

7 N-termini

5 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV
        70         80         90        100        110        120
EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG
       130        140        150        160        170        180
EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST
       190        200        210        220        230        240
RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV
       250        260        270        280        290
AAVLVTLILL GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV

Isoforms

- Isoform 2 of Junctional adhesion molecule A

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y624-27-	GSVTVH...	27		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y624-28-	SVTVHS...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y624-28-	SVTVHS...	28		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y624-28-	SVTVHS...	28		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9Y624-28-	SVTVHS...	28		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y624-28-	SVTVHS...	28		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y624-28-	SVTVHS...	28		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9Y624-28-unknown	SVTVHS...	28	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y624-157-unknown	DGSPPS...	157	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19885
Q9Y624-159-unknown	SPPSEY...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18188
Q9Y624-159-unknown	SPPSEY...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19886
Q9Y624-163-unknown	EYTWFK...	163	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19887
Q9Y624-169-unknown	DGIVMP...	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19888

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TCSEQD	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19885
...SEQDGS	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18188
...SEQDGS	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19886
...GSPPSE	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19887
...YTWFKD	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19888
...SSFLV	299	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	156	SEQD.\|.DGSP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	158	QDGS.\|.SPPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	158	QDGS.\|.SPPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	162	PPSE.\|.EYTW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	168	WFKD.\|.DGIV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)