P49773: Histidine triad nucleotide-binding protein 1

General Information

Protein names	- Histidine triad nucleotide-binding protein 1 - 3.-.-.- - Adenosine 5'-monophosphoramidase - Protein kinase C inhibitor 1 - Protein kinase C-interacting protein 1 - PKCI-1
Gene names	HINT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49773

8 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI
        70         80         90        100        110        120
SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ

MHWPPG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49773-2-unknown	MADEIA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49773-2-Acetylation	ADEIAK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49773-2-Acetylation	ADEIAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49773-2-Acetylation	ADEIAK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49773-2-Acetylation	ADEIAK...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P49773-10-unknown	VARPGG...	10			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49773-10-	VARPGG...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49773-10-	VARPGG...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49773-12-unknown	RPGGDT...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5945
P49773-12-unknown	RPGGDT...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7522
P49773-70-unknown	DESLLG...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19165
P49773-85-	AADLGL...	85			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49773-96-	MVVNEG...	96			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAQVAR	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5945
...KAQVAR	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7522
...VAEDDD	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19165
...HWPPG	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	11	QVAR.\|.RPGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	11	QVAR.\|.RPGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	69	EDDD.\|.DESL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)