Q9NQC3: Reticulon-4 {ECO:0000305}

General Information

Protein names	- Reticulon-4 {ECO:0000305} - Foocen - Neurite outgrowth inhibitor - Nogo protein {ECO:0000303\|PubMed:12488097} - Neuroendocrine-specific protein - NSP - Neuroendocrine-specific protein C homolog - RTN-x - Reticulon-5
Gene names	RTN4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NQC3

16 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Reticulon-4 - Isoform 3 of Reticulon-4 - Isoform 4 of Reticulon-4 - Isoform 5 of Reticulon-4 - Isoform 6 of Reticulon-4 - Isoform B of Reticulon-4 - Isoform C of Reticulon-4 - Isoform 6 of Reticulon-4 - Isoform B2 of Reticulon-4 - Isoform D of Reticulon-4

Sequence View

        10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE         10         20         30         40         50         60
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE ELEVLERKPA
        70         80         90        100        110        120
AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV APERQPSWDP SPVSSTVPAP
       130        140        150        160        170        180
SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS VSPQAEPVWT PPAPAPAAPP STPAAPKRRG
       190        200        210        220        230        240
SSGSVDETLF ALPAASEPVI RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP
       250        260        270        280        290        300
LSAASFKEHE YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
       310        320        330        340        350        360
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL TKLVKEDEVV
       370        380        390        400        410        420
SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK EDSDMLAAGG KIESNLESKV
       430        440        450        460        470        480
DKKCFADSLE QTNHEKDSES SNDDTSFPST PEGIKDRSGA YITCAPFNPA ATESIATNIF
       490        500        510        520        530        540
PLLGDPTSEN KTDEKKIEEK KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE
       550        560        570        580        590        600
EVVANMPEGL TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
       610        620        630        640        650        660
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK HEPENPPPYE
       670        680        690        700        710        720
EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD LIKETKLSAE PAPDFSDYSE
       730        740        750        760        770        780
MAKVEQPVPD HSELVEDSSP DSEPVDLFSD DSIPDVPQKQ DETVMLVKES LTETSFESMI
       790        800        810        820        830        840
EYENKEKLSA LPPEGGKPYL ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY
       850        860        870        880        890        900
SNDDLFISKE AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
       910        920        930        940        950        960
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL LPPDVSALAT
       970        980        990       1000       1010       1020
QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL SKTSVVDLLY WRDIKKTGVV
      1030       1040       1050       1060       1070       1080
FGASLFLLLS LTVFSIVSVT AYIALALLSV TISFRIYKGV IQAIQKSDEG HPFRAYLESE
      1090       1100       1110       1120       1130       1140
VAISEELVQK YSNSALGHVN CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL
      1150       1160       1170       1180       1190
LILALISLFS VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

16 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQC3-1-unknown	MEDLDQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88350
Q9NQC3-1-unknown	MEDLDQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88352
Q9NQC3-1-unknown	MEDLDQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88353
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102648
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102649
Q9NQC3-1-Acetylation	MEDLDQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102650
Q9NQC3-14-unknown	DSPPRP...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19807
Q9NQC3-14-unknown	DSPPRP...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136473
Q9NQC3-14-unknown	DSPPRP...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136474
Q9NQC3-14-unknown	DSPPRP...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136475
Q9NQC3-27-	FVREPE...	27			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NQC3-27-unknown	FVREPE...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176774
Q9NQC3-27-unknown	FVREPE...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176775
Q9NQC3-27-unknown	FVREPE...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176776
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NQC3-65-	AAPVPT...	65			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NQC3-65-unknown	AAPVPT...	65			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQC3-65-unknown	AAPVPT...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162045
Q9NQC3-65-unknown	AAPVPT...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162046
Q9NQC3-81-unknown	FGNDFV...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13380
Q9NQC3-81-unknown	FGNDFV...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141345
Q9NQC3-81-unknown	FGNDFV...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141346
Q9NQC3-85-	FVPPAP...	85			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NQC3-85-	FVPPAP...	85			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NQC3-85-unknown	FVPPAP...	85			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQC3-85-unknown	FVPPAP...	85		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162048
Q9NQC3-85-unknown	FVPPAP...	85		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162049
Q9NQC3-158-unknown	VWTPPA...	158			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQC3-158-unknown	VWTPPA...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162057
Q9NQC3-158-unknown	VWTPPA...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162058
Q9NQC3-158-	VWTPPA...	158			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9NQC3-158-	VWTPPA...	158			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q9NQC3-168-unknown	APPSTP...	168		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19811
Q9NQC3-168-unknown	APPSTP...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145448
Q9NQC3-207-unknown	MDLKEQ...	207		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88354
Q9NQC3-906-unknown	GAGSLP...	906			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQC3-906-unknown	GAGSLP...	906		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162052
Q9NQC3-906-unknown	GAGSLP...	906		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162051
Q9NQC3-909-unknown	SLPCTE...	909			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQC3-909-unknown	SLPCTE...	909		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162055
Q9NQC3-909-unknown	SLPCTE...	909		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162054

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVSSSD	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19807
...APLMDF	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13380
...APLMDF	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124513
...APLMDF	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124514
...APAPAA	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19811
...APAPAA	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128743
...APAPAA	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128744
...KRKAE	1192	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRKAE	1192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83969
...KRKAE	1192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83968
...KRKAE	1192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83971
...KRKAE	1192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83970
...KRKAE	1192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83972

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	13	SSSD.\|.DSPP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	80	LMDF.\|.FGND	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	167	APAA.\|.APPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)