P06753: Tropomyosin alpha-3 chain

General Information

Protein names	- Tropomyosin alpha-3 chain - Gamma-tropomyosin - Tropomyosin-3 - Tropomyosin-5 - hTM5
Gene names	TPM3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06753

11 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Tropomyosin alpha-3 chain - Isoform 3 of Tropomyosin alpha-3 chain - Isoform 4 of Tropomyosin alpha-3 chain - Isoform 5 of Tropomyosin alpha-3 chain - Isoform 6 of Tropomyosin alpha-3 chain - Isoform 7 of Tropomyosin alpha-3 chain

Sequence View

        10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI         10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI         10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI         10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI         10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI         10         20         30         40         50         60
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK LKGTEDELDK
        70         80         90        100        110        120
YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL DRAQERLATA LQKLEEAEKA
       130        140        150        160        170        180
ADESERGMKV IENRALKDEE KMELQEIQLK EAKHIAEEAD RKYEEVARKL VIIEGDLERT
       190        200        210        220        230        240
EERAELAESK CSELEEELKN VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA
       250        260        270        280
EFAERSVAKL EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06753-1-unknown	MMEAIK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06753-1-acetylation	MMEAIK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P06753-2-	MEAIKK...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-2-acetylation	MEAIKK...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-2-acetylation	MEAIKK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06753-3-	EAIKKK...	3			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-13-	KLDKEN...	13			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-43-Pyrrolidone carboxylic acid (Glu)	ELAAMQ...	43	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-43-	ELAAMQ...	43			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92874
P06753-128-unknown	MKVIEN...	128		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000307712
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107237
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107238
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107239
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107240
P06753-128-unknown	MKVIEN...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107241
P06753-177-unknown	LERTEE...	177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11085
P06753-177-unknown	LERTEE...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139166
P06753-177-unknown	LERTEE...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144295
P06753-177-unknown	LERTEE...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144296
P06753-256-unknown	DLEDEL...	256		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18544
P06753-256-unknown	DLEDEL...	256		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147317

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLELAE	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426306
...IIEGDL	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11085
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122239
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127552
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127554
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127555
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127557
...IIEGDL	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127558
...EKTIDD	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18544
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130660
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155790
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155791
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155792
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155793
...EKTIDD	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155794
...DMTSI	285	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DMTSI	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88491

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	176	EGDL.\|.LERT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	255	TIDD.\|.DLED	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)