Q14574: Desmocollin-3

General Information

Protein names	- Desmocollin-3 - Cadherin family member 3 - Desmocollin-4 - HT-CP
Gene names	DSC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14574

4 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAGPRRSV RGAVCLHLLL TLVIFSRAGE ACKKVILNVP SKLEADKIIG RVNLEECFRS
        70         80         90        100        110        120
ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS
       130        140        150        160        170        180
KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK
       190        200        210        220        230        240
EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH
       250        260        270        280        290        300
PVFTEAIYNF EVLESSRPGT TVGVVCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS
       310        320        330        340        350        360
TGVITTVSHY LDREVVDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY
       370        380        390        400        410        420
EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSVV
       430        440        450        460        470        480
KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI
       490        500        510        520        530        540
KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP
       550        560        570        580        590        600
KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YVVICKPKMG YTDILAVDPD
       610        620        630        640        650        660
EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA
       670        680        690        700        710        720
TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG
       730        740        750        760        770        780
KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE
       790        800        810        820        830        840
MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EKLHRCNQNE
       850        860        870        880        890
DRMPSQDYVL TYNYEGRGSP AGSVGCCSEK QEEDGLDFLN NLEPKFITLA EACTKR

Isoforms

- Isoform 3B of Desmocollin-3

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14574-1-unknown	MAAAGP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73270
Q14574-28-unknown	AGEACK...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14574-28-unknown	AGEACK...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114368
Q14574-39-unknown	VPSKLE...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17939
Q14574-39-unknown	VPSKLE...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19520
Q14574-39-unknown	VPSKLE...	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138228
Q14574-136-unknown	RWAPIP...	136	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14574-136-unknown	RWAPIP...	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115932

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVILNV	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17939
...KVILNV	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19520
...KVILNV	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121258
...ACTKR	896	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	38	ILNV.\|.VPSK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	38	ILNV.\|.VPSK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)