P26641: Elongation factor 1-gamma

General Information

Protein names	- Elongation factor 1-gamma - EF-1-gamma - eEF-1B gamma
Gene names	EEF1G
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P26641

17 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA
        70         80         90        100        110        120
FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI
       130        140        150        160        170        180
MHHNKQATEN AKEEVRRILG LLDAYLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF
       190        200        210        220        230        240
RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE
       250        260        270        280        290        300
KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE
       310        320        330        340        350        360
DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV
       370        380        390        400        410        420
ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEETQ TLVREYFSWE
       430
GAFQHVGKAF NQGKIFK

Isoforms

- Isoform 2 of Elongation factor 1-gamma

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26641-2-unknown	MAAGTL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26641-2-	AAGTLY...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P26641-2-	AAGTLY...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P26641-2-Acetylation	AAGTLY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26641-2-Acetylation	AAGTLY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P26641-2-Acetylation	AAGTLY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26641-3-acetylation	AGTLYT...	3	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P26641-18-	ALIAAQ...	18			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P26641-33-unknown	SAPPHF...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5741
P26641-65-unknown	DGFCVF...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2548
P26641-74-	AIAYYV...	74			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26641-74-	AIAYYV...	74			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P26641-74-	AIAYYV...	74			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P26641-76-	AYYVSN...	76			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26641-78-	YVSNEE...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26641-78-	YVSNEE...	78			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P26641-106-unknown	IVPPAS...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2549
P26641-254-	AAAPAP...	254			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P26641-254-	AAAPAP...	254			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P26641-264-unknown	DECEQA...	264		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18988
P26641-265-unknown	ECEQAL...	265		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2550
P26641-267-unknown	EQALAA...	267		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18989
P26641-368-	SSSISG...	368			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P26641-368-	SSSISG...	368			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P26641-419-unknown	WEGAFQ...	419		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18990
P26641-419-unknown	WEGAFQ...	419		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3741

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVRVLS	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5741
...AFEGDD	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2548
...FADSDI	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2549
...PEEEMD	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18988
...EEEMDE	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2550
...EMDECE	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18989
...REYFSW	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18990
...REYFSW	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3741
...GKIFK	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	32	RVLS.\|.SAPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	64	EGDD.\|.DGFC	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	105	DSDI.\|.IVPP	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1B_HUMAN	263	EEMD.\|.DECE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP6_HUMAN	264	EMDE.\|.ECEQ	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
MEP1B_HUMAN	266	DECE.\|.EQAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	418	YFSW.\|.WEGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	418	YFSW.\|.WEGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)