Q6ZMP0: Thrombospondin type-1 domain-containing protein 4
Protein names | - Thrombospondin type-1 domain-containing protein 4 - A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6 - ADAMTS-like protein 6 - ADAMTSL-6 |
---|---|
Gene names | THSD4 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6ZMP0 |
3
N-termini
2
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
70 80 90 100 110 120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
130 140 150 160 170 180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
190 200 210 220 230 240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
250 260 270 280 290 300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
310 320 330 340 350 360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
370 380 390 400 410 420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
430 440 450 460 470 480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
490 500 510 520 530 540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
550 560 570 580 590 600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
610 620 630 640 650 660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
670 680 690 700 710 720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
730 740 750 760 770 780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
790 800 810 820 830 840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
850 860 870 880 890 900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
910 920 930 940 950 960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
970 980 990 1000 1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR
Isoforms
- Isoform 2 of Thrombospondin type-1 domain-containing protein 4 - Isoform 3 of Thrombospondin type-1 domain-containing protein 4 - Isoform 4 of Thrombospondin type-1 domain-containing protein 4Sequence View
10 20 30 40 50 60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
70 80 90 100 110 120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
130 140 150 160 170 180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
190 200 210 220 230 240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
250 260 270 280 290 300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
310 320 330 340 350 360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
370 380 390 400 410 420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
430 440 450 460 470 480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
490 500 510 520 530 540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
550 560 570 580 590 600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
610 620 630 640 650 660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
670 680 690 700 710 720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
730 740 750 760 770 780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
790 800 810 820 830 840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
850 860 870 880 890 900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
910 920 930 940 950 960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
970 980 990 1000 1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR
10 20 30 40 50 60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
70 80 90 100 110 120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
130 140 150 160 170 180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
190 200 210 220 230 240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
250 260 270 280 290 300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
310 320 330 340 350 360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
370 380 390 400 410 420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
430 440 450 460 470 480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
490 500 510 520 530 540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
550 560 570 580 590 600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
610 620 630 640 650 660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
670 680 690 700 710 720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
730 740 750 760 770 780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
790 800 810 820 830 840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
850 860 870 880 890 900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
910 920 930 940 950 960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
970 980 990 1000 1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR
10 20 30 40 50 60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
70 80 90 100 110 120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
130 140 150 160 170 180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
190 200 210 220 230 240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
250 260 270 280 290 300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
310 320 330 340 350 360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
370 380 390 400 410 420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
430 440 450 460 470 480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
490 500 510 520 530 540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
550 560 570 580 590 600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
610 620 630 640 650 660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
670 680 690 700 710 720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
730 740 750 760 770 780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
790 800 810 820 830 840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
850 860 870 880 890 900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
910 920 930 940 950 960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
970 980 990 1000 1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6ZMP0-1-unknown | MVSHFM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92122 | |||
Q6ZMP0-26-unknown | QPSTQH... | 26 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6ZMP0-26-unknown | QPSTQH... | 26 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113936 | |||
Q6ZMP0-332-unknown | EWEPFA... | 332 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18008 | |||
Q6ZMP0-332-unknown | EWEPFA... | 332 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19650 | |||
Q6ZMP0-332-unknown | EWEPFA... | 332 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150566 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...MGRFYE | 331 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC18008 | |||
...MGRFYE | 331 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC19650 | |||
...MGRFYE | 331 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133963 | |||
...FLGSR | 1018 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...FLGSR | 1018 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87742 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MEP1A_HUMAN | 331 | RFYE.|.EWEP | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
MEP1B_HUMAN | 331 | RFYE.|.EWEP | inferred from experiment | unknown | MEROPS | Overall CM | Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) | 21693781, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|