Q6ZMP0: Thrombospondin type-1 domain-containing protein 4

General Information

Protein names	- Thrombospondin type-1 domain-containing protein 4 - A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6 - ADAMTS-like protein 6 - ADAMTSL-6
Gene names	THSD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6ZMP0

3 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
        70         80         90        100        110        120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
       130        140        150        160        170        180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
       190        200        210        220        230        240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
       250        260        270        280        290        300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
       310        320        330        340        350        360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
       370        380        390        400        410        420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
       430        440        450        460        470        480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
       490        500        510        520        530        540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
       550        560        570        580        590        600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
       610        620        630        640        650        660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
       670        680        690        700        710        720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
       730        740        750        760        770        780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
       790        800        810        820        830        840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
       850        860        870        880        890        900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
       910        920        930        940        950        960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
       970        980        990       1000       1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR

Isoforms

- Isoform 2 of Thrombospondin type-1 domain-containing protein 4 - Isoform 3 of Thrombospondin type-1 domain-containing protein 4 - Isoform 4 of Thrombospondin type-1 domain-containing protein 4

Sequence View

        10         20         30         40         50         60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
        70         80         90        100        110        120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
       130        140        150        160        170        180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
       190        200        210        220        230        240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
       250        260        270        280        290        300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
       310        320        330        340        350        360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
       370        380        390        400        410        420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
       430        440        450        460        470        480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
       490        500        510        520        530        540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
       550        560        570        580        590        600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
       610        620        630        640        650        660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
       670        680        690        700        710        720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
       730        740        750        760        770        780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
       790        800        810        820        830        840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
       850        860        870        880        890        900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
       910        920        930        940        950        960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
       970        980        990       1000       1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR         10         20         30         40         50         60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
        70         80         90        100        110        120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
       130        140        150        160        170        180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
       190        200        210        220        230        240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
       250        260        270        280        290        300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
       310        320        330        340        350        360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
       370        380        390        400        410        420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
       430        440        450        460        470        480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
       490        500        510        520        530        540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
       550        560        570        580        590        600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
       610        620        630        640        650        660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
       670        680        690        700        710        720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
       730        740        750        760        770        780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
       790        800        810        820        830        840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
       850        860        870        880        890        900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
       910        920        930        940        950        960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
       970        980        990       1000       1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR         10         20         30         40         50         60
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG
        70         80         90        100        110        120
PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE
       130        140        150        160        170        180
TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT
       190        200        210        220        230        240
DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA
       250        260        270        280        290        300
PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL
       310        320        330        340        350        360
CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ
       370        380        390        400        410        420
AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH
       430        440        450        460        470        480
ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT
       490        500        510        520        530        540
MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH
       550        560        570        580        590        600
RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH
       610        620        630        640        650        660
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS
       670        680        690        700        710        720
SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ
       730        740        750        760        770        780
HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL
       790        800        810        820        830        840
RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA
       850        860        870        880        890        900
EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK
       910        920        930        940        950        960
PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE
       970        980        990       1000       1010
SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6ZMP0-1-unknown	MVSHFM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt92122
Q6ZMP0-26-unknown	QPSTQH...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6ZMP0-26-unknown	QPSTQH...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113936
Q6ZMP0-332-unknown	EWEPFA...	332	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18008
Q6ZMP0-332-unknown	EWEPFA...	332	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19650
Q6ZMP0-332-unknown	EWEPFA...	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150566

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MGRFYE	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18008
...MGRFYE	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19650
...MGRFYE	331	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133963
...FLGSR	1018	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FLGSR	1018	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87742

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	331	RFYE.\|.EWEP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	331	RFYE.\|.EWEP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

TopFIND

Q6ZMP0: Thrombospondin type-1 domain-containing protein 4

General Information

3

N-termini

2

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates