P35052: Glypican-1

General Information

Protein names	- Glypican-1 - Secreted glypican-1
Gene names	GPC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35052

3 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR
        70         80         90        100        110        120
ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER
       130        140        150        160        170        180
TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP
       190        200        210        220        230        240
QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV
       250        260        270        280        290        300
PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI
       310        320        330        340        350        360
TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR
       370        380        390        400        410        420
RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA
       430        440        450        460        470        480
RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD
       490        500        510        520        530        540
ASDDGSGSGS GDGCLDDLCS RKVSRKSSSS RTPLTHALPG LSEQEGQKTS AASCPQPPTF
       550
LLPLLLFLAL TVARPRWR

Isoforms

- Isoform 2 of Glypican-1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35052-24-unknown	DPASKS...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P35052-48-unknown	DVPQAE...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17604
P35052-439-unknown	NPEVEV...	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19063
P35052-439-unknown	NPEVEV...	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17605

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GFSLSD	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17604
...FGEAPR	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410251
...ASDVVR	234	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389276
...GKLAPR	366	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392629
...ANQINN	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19063
...ANQINN	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17605
...EGQKTS	529	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390242
...GQKTSA	530	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	47	SLSD.\|.DVPQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	438	QINN.\|.NPEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	438	QINN.\|.NPEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)