P30042: ES1 protein homolog, mitochondrial

General Information

Protein names	- ES1 protein homolog, mitochondrial - Protein GT335 - Protein KNP-I
Gene names	C21orf33
Organism	Homo sapiens
Protease Family
Protease ID	C56.975
Chromosome location	q22.3
UniProt ID	P30042

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVRVLVAS RLAAASAFTS LSPGGRTPSQ RAALHLSVPR PAARVALVLS GCGVYDGTEI
        70         80         90        100        110        120
HEASAILVHL SRGGAEVQIF APDVPQMHVI DHTKGQPSEG ESRNVLTESA RIARGKITDL
       130        140        150        160        170        180
ANLSAANHDA AIFPGGFGAA KNLSTFAVDG KDCKVNKEVE RVLKEFHQAG KPIGLCCIAP
       190        200        210        220        230        240
VLAAKVLRGV EVTVGHEQEE GGKWPYAGTA EAIKALGAKH CVKEVVEAHV DQKNKVVTTP
       250        260
AFMCETALHY IHDGIGAMVR KVLELTGK

Isoforms

- Isoform Short of ES1 protein homolog, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30042-1-unknown	MAAVRV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74174
P30042-34-	LHLSVP...	34		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30042-34-unknown	LHLSVP...	34	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178486
P30042-42-unknown	AARVAL...	42	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30042-42-unknown	AARVAL...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115473
P30042-129-unknown	DAAIFP...	129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19017
P30042-132-unknown	IFPGGF...	132	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17559

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SAANHD	128	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19017
...SAANHD	128	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127091
...NHDAAI	131	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17559
...NHDAAI	131	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127217
...ELTGK	268		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ELTGK	268		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ELTGK	268	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ELTGK	268	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69792
...ELTGK	268		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ELTGK	268		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	128	ANHD.\|.DAAI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	131	DAAI.\|.IFPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)