P17987: T-complex protein 1 subunit alpha

General Information

Protein names	- T-complex protein 1 subunit alpha - TCP-1-alpha - CCT-alpha
Gene names	TCP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17987

18 N-termini

15 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGPLSVFGD RSTGETIRSQ NVMAAASIAN IVKSSLGPVG LDKMLVDDIG DVTITNDGAT
        70         80         90        100        110        120
ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL LKNADELVKQ KIHPTSVISG
       130        140        150        160        170        180
YRLACKEAVR YINENLIVNT DELGRDCLIN AAKTSMSSKI IGINGDFFAN MVVDAVLAIK
       190        200        210        220        230        240
YTDIRGQPRY PVNSVNILKA HGRSQMESML ISGYALNCVV GSQGMPKRIV NAKIACLDFS
       250        260        270        280        290        300
LQKTKMKLGV QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMCLKYF
       310        320        330        340        350        360
VEAGAMAVRR VLKRDLKRIA KASGATILST LANLEGEETF EAAMLGQAEE VVQERICDDE
       370        380        390        400        410        420
LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK RVLESKSVVP GGGAVEAALS
       430        440        450        460        470        480
IYLENYATSM GSREQLAIAE FARSLLVIPN TLAVNAAQDS TDLVAKLRAF HNEAQVNPER
       490        500        510        520        530        540
KNLKWIGLDL SNGKPRDNKQ AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD
       550
KHGSYEDAVH SGALND

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

18 N-termini - 15 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17987-1-Acetylation	MEGPLS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17987-1-Acetylation	MEGPLS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P17987-1-Acetylation	MEGPLS...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P17987-1-Acetylation	MEGPLS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P17987-1-Acetylation	MEGPLS...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P17987-23-unknown	MAAASI...	23		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439671
P17987-23-unknown	MAAASI...	23		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437840
P17987-23-unknown	MAAASI...	23		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442856
P17987-24-	AAASIA...	24			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P17987-31-unknown	IVKSSL...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14017
P17987-34-	SSLGPV...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17987-34-	SSLGPV...	34			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P17987-34-	SSLGPV...	34			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P17987-156-unknown	MSSKII...	156		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000376008
P17987-219-unknown	VVGSQG...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3665
P17987-225-unknown	MPKRIV...	225		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439447
P17987-252-unknown	VVITDP...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5631
P17987-344-	MLGQAE...	344			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P17987-344-	MLGQAE...	344			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17987-344-	MLGQAE...	344			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17987-344-	MLGQAE...	344			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P17987-346-	GQAEEV...	346			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17987-346-	GQAEEV...	346			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17987-347-unknown	QAEEVV...	347		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7350
P17987-360-unknown	ELILIK...	360		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11272
P17987-456-unknown	AAQDST...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5632
P17987-456-unknown	AAQDST...	456		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7351
P17987-469-acetylation	AFHNEA...	469	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P17987-472-unknown	NEAQVN...	472		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5633
P17987-472-unknown	NEAQVN...	472		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7352
P17987-477-unknown	NPERKN...	477		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18817
P17987-488-unknown	LDLSNG...	488		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7353

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASIANI	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14017
...KQKIHP	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442856
...VRYINE	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437840
...TSMSSK	158	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439671
...AVLAIK	179	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442185
...YALNCV	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3665
...KLGVQV	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5631
...AAMLGQ	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7350
...RICDDE	359	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11272
...LSIYLE	423	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441345
...TLAVNA	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5632
...TLAVNA	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7351
...LRAFHN	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5633
...LRAFHN	471	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7352
...NEAQVN	476	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18817
...LKWIGL	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7353
...GALND	556	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	30	IANI.\|.IVKS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	218	LNCV.\|.VVGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	251	GVQV.\|.VVIT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	346	MLGQ.\|.QAEE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	359	CDDE.\|.ELIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	455	AVNA.\|.AAQD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	455	AVNA.\|.AAQD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	471	AFHN.\|.NEAQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	471	AFHN.\|.NEAQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	476	AQVN.\|.NPER	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	487	WIGL.\|.LDLS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)