P10768: S-formylglutathione hydrolase

General Information

Protein names	- S-formylglutathione hydrolase - FGH - 3.1.2.12 - Esterase D - Methylumbelliferyl-acetate deacetylase - 3.1.1.56
Gene names	ESD
Organism	Homo sapiens
Protease Family
Protease ID	S09.990
Chromosome location
UniProt ID	P10768

9 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN
        70         80         90        100        110        120
FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM
       130        140        150        160        170        180
YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL
       190        200        210        220        230        240
CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI
       250        260        270        280
AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10768-2-unknown	MALKQI...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10768-2-unknown	MALKQI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10768-2-Acetylation	ALKQIS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10768-2-Acetylation	ALKQIS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P10768-2-Acetylation	ALKQIS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10768-21-unknown	HDSVEL...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5543
P10768-30-unknown	MKFAVY...	30		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000367969
P10768-54-unknown	LTCTEQ...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3610
P10768-56-unknown	CTEQNF...	56		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7274
P10768-76-unknown	LVVIAP...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3611
P10768-201-	AYDATH...	201			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P10768-231-unknown	DGQLLP...	231		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17278
P10768-231-unknown	DGQLLP...	231		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18650

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKVFEH	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5543
...YWLSGL	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3610
...LSGLTC	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7274
...ASEHGL	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3611
...DQFLLD	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17278
...DQFLLD	230	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18650
...KYLNA	282	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	20	VFEH.\|.HDSV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	53	LSGL.\|.LTCT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	55	GLTC.\|.CTEQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	75	EHGL.\|.LVVI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	230	FLLD.\|.DGQL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	230	FLLD.\|.DGQL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)