P30048: Thioredoxin-dependent peroxide reductase, mitochondrial

General Information

Protein names	- Thioredoxin-dependent peroxide reductase, mitochondrial - 1.11.1.15 {ECO:0000269\|PubMed:17707404, ECO:0000269\|PubMed:19462976} - Antioxidant protein 1 - AOP-1 - HBC189 - Peroxiredoxin III - Prx-III - Peroxiredoxin-3 - Protein MER5 homolog
Gene names	PRDX3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30048

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC
        70         80         90        100        110        120
HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN
       130        140        150        160        170        180
EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG
       190        200        210        220        230        240
LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI
       250
KPSPAASKEY FQKVNQ

Isoforms

- Isoform 2 of Thioredoxin-dependent peroxide reductase, mitochondrial

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30048-1-unknown	MAAAVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86150
P30048-55-unknown	STSSSC...	55		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30048-55-	STSSSC...	55		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30048-63-unknown	PAVTQH...	63	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30048-64-	AVTQHA...	64		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30048-199-	SVNDLP...	199		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P30048-199-	SVNDLP...	199		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P30048-199-unknown	SVNDLP...	199		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30048-199-unknown	SVNDLP...	199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161939
P30048-233-unknown	WTPDSP...	233	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19020
P30048-233-unknown	WTPDSP...	233	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147163
P30048-237-unknown	SPTIKP...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17561
P30048-237-unknown	SPTIKP...	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147321

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VCPANW	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19020
...VCPANW	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130501
...NWTPDS	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17561
...NWTPDS	236	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130664
...QKVNQ	256	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKVNQ	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81768

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	232	PANW.\|.WTPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	236	TPDS.\|.SPTI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)