Q5TCX8: Mitogen-activated protein kinase kinase kinase 21

General Information

Protein names	- Mitogen-activated protein kinase kinase kinase 21 - 2.7.11.25 - Mitogen-activated protein kinase kinase kinase MLK4 - Mixed lineage kinase 4
Gene names	MLK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5TCX8

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR
        70         80         90        100        110        120
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA
       130        140        150        160        170        180
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH
       190        200        210        220        230        240
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW
       250        260        270        280        290        300
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT
       310        320        330        340        350        360
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK
       370        380        390        400        410        420
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD
       430        440        450        460        470        480
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN
       490        500        510        520        530        540
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS
       550        560        570        580        590        600
SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM
       610        620        630        640        650        660
KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK
       670        680        690        700        710        720
QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE
       730        740        750        760        770        780
SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL
       790        800        810        820        830        840
PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP
       850        860        870        880        890        900
TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT
       910        920        930        940        950        960
PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY
       970        980        990       1000       1010       1020
PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS
      1030
KTSRPSIYEL EKEFLS

Isoforms

- Isoform 2 of Mitogen-activated protein kinase kinase kinase MLK4 - Isoform 3 of Mitogen-activated protein kinase kinase kinase MLK4 - Isoform 2 of Mitogen-activated protein kinase kinase kinase 21 - Isoform 3 of Mitogen-activated protein kinase kinase kinase 21

Sequence View

        10         20         30         40         50         60
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR
        70         80         90        100        110        120
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA
       130        140        150        160        170        180
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH
       190        200        210        220        230        240
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW
       250        260        270        280        290        300
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT
       310        320        330        340        350        360
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK
       370        380        390        400        410        420
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD
       430        440        450        460        470        480
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN
       490        500        510        520        530        540
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS
       550        560        570        580        590        600
SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM
       610        620        630        640        650        660
KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK
       670        680        690        700        710        720
QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE
       730        740        750        760        770        780
SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL
       790        800        810        820        830        840
PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP
       850        860        870        880        890        900
TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT
       910        920        930        940        950        960
PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY
       970        980        990       1000       1010       1020
PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS
      1030
KTSRPSIYEL EKEFLS         10         20         30         40         50         60
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR
        70         80         90        100        110        120
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA
       130        140        150        160        170        180
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH
       190        200        210        220        230        240
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW
       250        260        270        280        290        300
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT
       310        320        330        340        350        360
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK
       370        380        390        400        410        420
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD
       430        440        450        460        470        480
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN
       490        500        510        520        530        540
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS
       550        560        570        580        590        600
SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM
       610        620        630        640        650        660
KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK
       670        680        690        700        710        720
QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE
       730        740        750        760        770        780
SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL
       790        800        810        820        830        840
PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP
       850        860        870        880        890        900
TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT
       910        920        930        940        950        960
PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY
       970        980        990       1000       1010       1020
PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS
      1030
KTSRPSIYEL EKEFLS         10         20         30         40         50         60
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR
        70         80         90        100        110        120
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA
       130        140        150        160        170        180
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH
       190        200        210        220        230        240
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW
       250        260        270        280        290        300
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT
       310        320        330        340        350        360
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK
       370        380        390        400        410        420
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD
       430        440        450        460        470        480
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN
       490        500        510        520        530        540
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS
       550        560        570        580        590        600
SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM
       610        620        630        640        650        660
KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK
       670        680        690        700        710        720
QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE
       730        740        750        760        770        780
SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL
       790        800        810        820        830        840
PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP
       850        860        870        880        890        900
TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT
       910        920        930        940        950        960
PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY
       970        980        990       1000       1010       1020
PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS
      1030
KTSRPSIYEL EKEFLS         10         20         30         40         50         60
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR
        70         80         90        100        110        120
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA
       130        140        150        160        170        180
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH
       190        200        210        220        230        240
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW
       250        260        270        280        290        300
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT
       310        320        330        340        350        360
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK
       370        380        390        400        410        420
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD
       430        440        450        460        470        480
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN
       490        500        510        520        530        540
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS
       550        560        570        580        590        600
SSSPPSSPTM MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM
       610        620        630        640        650        660
KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS PDGLEHRKPK
       670        680        690        700        710        720
QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV SIEMTPTNSL SRSPQRKKTE
       730        740        750        760        770        780
SALYGCTVLL ASVALGLDLR ELHKAQAAEE PLPKEEKKKR EGIFQRASKS RRSASPPTSL
       790        800        810        820        830        840
PSTCGEASSP PSLPLSSALG ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP
       850        860        870        880        890        900
TAPGSGREPA LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT
       910        920        930        940        950        960
PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL RSRSDLPQAY
       970        980        990       1000       1010       1020
PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL DADVEGQSRD YTVPLCRMRS
      1030
KTSRPSIYEL EKEFLS

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q5TCX8-1-unknown	MALRGA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q5TCX8-1-unknown	MALRGA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80181
Q5TCX8-211-unknown	ALAAAN...	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19625
Q5TCX8-211-unknown	ALAAAN...	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147013

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GALNRA	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19625
...GALNRA	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130346
...KEFLS	1036	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KEFLS	1036	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75800

TopFIND

Q5TCX8: Mitogen-activated protein kinase kinase kinase 21

General Information

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates