P67809: Nuclease-sensitive element-binding protein 1

General Information

Protein names	- Nuclease-sensitive element-binding protein 1 - CCAAT-binding transcription factor I subunit A - CBF-A - DNA-binding protein B - DBPB - Enhancer factor I subunit A - EFI-A - Y-box transcription factor - Y-box-binding protein 1 - YB-1
Gene names	YBX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P67809

41 N-termini

21 C-termini

24 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSEAETQQP PAAPPAAPAL SAADTKPGTT GSGAGSGGPG GLTSAAPAGG DKKVIATKVL
        70         80         90        100        110        120
GTVKWFNVRN GYGFINRNDT KEDVFVHQTA IKKNNPRKYL RSVGDGETVE FDVVEGEKGA
       130        140        150        160        170        180
EAANVTGPGG VPVQGSKYAA DRNHYRRYPR RRGPPRNYQQ NYQNSESGEK NEGSESAPEG
       190        200        210        220        230        240
QAQQRRPYRR RRFPPYYMRR PYGRRPQYSN PPVQGEVMEG ADNQGAGEQG RPVRQNMYRG
       250        260        270        280        290        300
YRPRFRRGPP RQRQPREDGN EEDKENQGDE TQGQQPPQRR YRRNFNYRRR RPENPKPQDG
       310        320
KETKAADPPA ENSSAPEAEQ GGAE

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

41 N-termini - 21 C-termini - 24 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P67809-2-unknown	MSSEAE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P67809-2-Acetylation	SSEAET...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P67809-2-Acetylation	SSEAET...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P67809-19-	ALSAAD...	19			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-21-	SAADTK...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-21-	SAADTK...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-21-	SAADTK...	21			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-22-	AADTKP...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-22-	AADTKP...	22			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-22-unknown	AADTKP...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6151
P67809-22-unknown	AADTKP...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7667
P67809-25-	TKPGTT...	25			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P67809-25-	TKPGTT...	25			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P67809-29-unknown	TTGSGA...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3903
P67809-31-unknown	GSGAGS...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3904
P67809-32-unknown	SGAGSG...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3905
P67809-36-unknown	SGGPGG...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3906
P67809-37-	GGPGGL...	37			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P67809-38-unknown	GPGGLT...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3907
P67809-41-	GLTSAA...	41			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P67809-44-unknown	SAAPAG...	44			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P67809-44-	SAAPAG...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-44-	SAAPAG...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P67809-44-	SAAPAG...	44			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-45-	AAPAGG...	45			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-45-	AAPAGG...	45			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-59-	VLGTVK...	59			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P67809-84-	VFVHQT...	84			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-113-unknown	VVEGEK...	113			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P67809-113-	VVEGEK...	113			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-113-	VVEGEK...	113			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P67809-113-	VVEGEK...	113			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-113-	VVEGEK...	113			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-116-	GEKGAE...	116			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-116-	GEKGAE...	116			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-116-	GEKGAE...	116			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P67809-116-	GEKGAE...	116			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P67809-122-	AANVTG...	122			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-124-	NVTGPG...	124			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P67809-124-	NVTGPG...	124			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-124-	NVTGPG...	124			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P67809-125-	VTGPGG...	125			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-160-unknown	QNYQNS...	160		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7668
P67809-164-unknown	NSESGE...	164		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6152
P67809-164-unknown	NSESGE...	164		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14291
P67809-164-unknown	NSESGE...	164		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7669
P67809-165-	SESGEK...	165			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P67809-171-unknown	NEGSES...	171		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10154
P67809-176-unknown	SAPEGQ...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19281
P67809-176-unknown	SAPEGQ...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7670
P67809-209-	SNPPVQ...	209			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P67809-209-	SNPPVQ...	209			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P67809-215-unknown	GEVMEG...	215		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6153
P67809-217-unknown	VMEGAD...	217		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11799
P67809-220-unknown	GADNQG...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7671
P67809-222-unknown	DNQGAG...	222		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19282
P67809-223-unknown	NQGAGE...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19283
P67809-223-unknown	NQGAGE...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17804
P67809-224-unknown	QGAGEQ...	224		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19284
P67809-259-unknown	GNEEDK...	259		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11800
P67809-264-unknown	KENQGD...	264		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3908
P67809-294-unknown	NPKPQD...	294		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17805
P67809-302-	ETKAAD...	302			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...APALSA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6151
...APALSA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7667
...DTKPGT	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3903
...KPGTTG	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3904
...PGTTGS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3905
...GSGAGS	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3906
...GAGSGG	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3907
...PRNYQQ	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7668
...QQNYQN	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6152
...QQNYQN	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14291
...QQNYQN	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7669
...ESGEKN	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10154
...NEGSES	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19281
...NEGSES	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7670
...NPPVQG	214	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6153
...PVQGEV	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11799
...GEVMEG	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7671
...VMEGAD	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19282
...MEGADN	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19283
...MEGADN	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17804
...EGADNQ	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19284
...RPRFRR	246	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405937
...QPREDG	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11800
...GNEEDK	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3908
...RRRPEN	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17805
...QGGAE	324	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	21	ALSA.\|.AADT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	21	ALSA.\|.AADT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	28	KPGT.\|.TTGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	30	GTTG.\|.GSGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	31	TTGS.\|.SGAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	35	GAGS.\|.SGGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	37	GSGG.\|.GPGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	159	NYQQ.\|.QNYQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	163	NYQN.\|.NSES	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	163	NYQN.\|.NSES	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	163	NYQN.\|.NSES	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	170	GEKN.\|.NEGS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1B_HUMAN	175	GSES.\|.SAPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	175	GSES.\|.SAPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	214	PVQG.\|.GEVM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	216	QGEV.\|.VMEG	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> YBOX1_HUMAN @216
GRAB_HUMAN	216	QGEV.\|.VMEG	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
CATS_HUMAN	219	VMEG.\|.GADN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	221	EGAD.\|.DNQG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	222	GADN.\|.NQGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	222	GADN.\|.NQGA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	223	ADNQ.\|.QGAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	258	REDG.\|.GNEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATB_HUMAN	263	EEDK.\|.KENQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	293	RPEN.\|.NPKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)