Q14116: Interleukin-18 {ECO:0000303|PubMed:14528293, ECO:0000303|PubMed:25261253, ECO:0000303|PubMed:25500532}

General Information

Protein names	- Interleukin-18 {ECO:0000303\|PubMed:14528293, ECO:0000303\|PubMed:25261253, ECO:0000303\|PubMed:25500532} - IL-18 {ECO:0000303\|PubMed:14528293, ECO:0000303\|PubMed:25261253, ECO:0000303\|PubMed:25500532} - Iboctadekin - Interferon gamma-inducing factor {ECO:0000303\|PubMed:14528293, ECO:0000303\|PubMed:25500532} - IFN-gamma-inducing factor {ECO:0000303\|PubMed:14528293, ECO:0000303\|PubMed:25500532} - Interleukin-1 gamma - IL-1 gamma
Gene names	IL18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14116

8 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ
        70         80         90        100        110        120
GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK
       130        140        150        160        170        180
EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL
       190
GDRSIMFTVQ NED

Isoforms

- Isoform 2 of Interleukin-18

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q14116-1-unknown	MAAEPV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77729
Q14116-2-acetylation	AAEPVE...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14116-2-acetylation	AAEPVE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183061
Q14116-37-unknown	YFGKLE...	37		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14116-37-unknown	YFGKLE...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1287
Q14116-37-unknown	YFGKLE...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2387
Q14116-37-unknown	YFGKLE...	37		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115319
Q14116-37-unknown	YFGKLE...	37		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q14116-52-unknown	NDQVLF...	52		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19500
Q14116-52-unknown	NDQVLF...	52		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138952
Q14116-58-unknown	IDQGNR...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8432
Q14116-58-unknown	IDQGNR...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139487
Q14116-72-unknown	SDCRDN...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2200
Q14116-72-unknown	SDCRDN...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140504
Q14116-77-unknown	NAPRTI...	77		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2202
Q14116-77-unknown	NAPRTI...	77		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140847
Q14116-152-unknown	ESSSYE...	152		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8434
Q14116-152-unknown	ESSSYE...	152		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144657

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...NLESDY	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1287
...NLESDY	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2387
...VIRNLN	51	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19500
...VIRNLN	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122019
...DQVLFI	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8432
...DQVLFI	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122577
...EDMTDS	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2200
...EDMTDS	71	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123631
...SDCRDN	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2202
...SDCRDN	76	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123987
...NKMQFE	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8434
...NKMQFE	151	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127924
...VQNED	193	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VQNED	193	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt73347
...VQNED	193		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VQNED	193		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VQNED	193		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VQNED	193		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	36	ESDY.\|.YFGK	inferred from experiment	unknown	MEROPS	Kurimoto M	Akita K et al.:Involvement of caspase-1 and ca... (C14.001)	9334240,
CASP4_HUMAN	36	ESDY.\|.YFGK	inferred from experiment	unknown	MEROPS	Ferrini S	Gaggero A et al.:A novel isoform of pro-interleu... (C14.007)	15326478,
MEP1B_HUMAN	51	RNLN.\|.NDQV	inferred from experiment	unknown	MEROPS	Bond JS	Banerjee S et al.:Prointerleukin-18 is activated ... (M12.004)	18786924,
CMA1_HUMAN	57	VLFI.\|.IDQG	inferred from experiment	unknown	MEROPS	Hellman L	Andersson MK et al.:The extended substrate specific... (S01.140)	19073880,
CASP3_HUMAN	71	MTDS.\|.SDCR	inferred from experiment	unknown	MEROPS	Kurimoto M	Akita K et al.:Involvement of caspase-1 and ca... (C14.001)	9334240,
CASP3_HUMAN	76	CRDN.\|.NAPR	inferred from experiment	unknown	MEROPS	Kurimoto M	Akita K et al.:Involvement of caspase-1 and ca... (C14.001)	9334240,
CMA1_HUMAN	151	MQFE.\|.ESSS	inferred from experiment	unknown	MEROPS	Hellman L	Andersson MK et al.:The extended substrate specific... (S01.140)	19073880,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)