P27348: 14-3-3 protein theta

General Information

Protein names	- 14-3-3 protein theta - 14-3-3 protein T-cell - 14-3-3 protein tau - Protein HS1
Gene names	YWHAQ
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P27348

14 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
        70         80         90        100        110        120
VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
       130        140        150        160        170        180
MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
       190        200        210        220        230        240
ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA

EGAEN

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P27348-1-Acetylation	MEKTEL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P27348-1-Acetylation	MEKTEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P27348-1-Acetylation	MEKTEL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P27348-1-Acetylation	MEKTEL...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P27348-24-	TCMKAV...	24			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P27348-28-	AVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27348-28-	AVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P27348-28-	AVTEQG...	28			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27348-30-	TEQGAE...	30			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P27348-31-unknown	EQGAEL...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7393
P27348-32-unknown	QGAELS...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7394
P27348-106-unknown	IANATN...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3742
P27348-144-unknown	NSQGAY...	144		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5742
P27348-145-unknown	SQGAYQ...	145		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3743
P27348-145-	SQGAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27348-145-	SQGAYQ...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P27348-145-	SQGAYQ...	145			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P27348-151-unknown	EAFDIS...	151		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7395
P27348-208-unknown	EDSYKD...	208		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18991
P27348-209-unknown	DSYKDS...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18992
P27348-239-unknown	AAEGAE...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2854
P27348-239-unknown	AAEGAE...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1763
P27348-239-unknown	AAEGAE...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3064

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKAVTE	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7393
...KAVTEQ	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7394
...LDKYLI	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3742
...KQTIDN	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5742
...QTIDNS	144	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3743
...SQGAYQ	149	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000398990
...QGAYQE	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7395
...LDTLNE	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18991
...DTLNED	208	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18992
...GEECDA	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2854
...GEECDA	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1763
...GEECDA	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3064
...EGAEN	245	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EGAEN	245		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EGAEN	245		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	30	AVTE.\|.EQGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	31	VTEQ.\|.QGAE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	105	KYLI.\|.IANA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	143	TIDN.\|.NSQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	144	IDNS.\|.SQGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	150	AYQE.\|.EAFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	207	TLNE.\|.EDSY	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	208	LNED.\|.DSYK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP7_HUMAN	238	ECDA.\|.AAEG	inferred from experiment	unknown	MEROPS	Tsujimoto Y	Nomura M et al.:14-3-3 Interacts directly with ... (C14.003)	12426317,
CASP3_HUMAN	238	ECDA.\|.AAEG	inferred from experiment	unknown	MEROPS	Tsujimoto Y	Nomura M et al.:14-3-3 Interacts directly with ... (C14.003)	12426317,
CASP8_HUMAN	238	ECDA.\|.AAEG	inferred from experiment	unknown	MEROPS	Tsujimoto Y	Nomura M et al.:14-3-3 Interacts directly with ... (C14.003)	12426317,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)