P16403: Histone H1.2

General Information

Protein names	- Histone H1.2 - Histone H1c - Histone H1d - Histone H1s-1
Gene names	HIST1H1C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16403

22 N-termini

12 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA
        70         80         90        100        110        120
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV
       130        140        150        160        170        180
KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA
       190        200        210
KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

22 N-termini - 12 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P16403-2-unknown	MSETAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16403-2-unknown	MSETAP...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16403-2-Acetylation	SETAPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16403-2-Acetylation	SETAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P16403-2-Acetylation	SETAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P16403-2-	SETAPA...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P16403-5-unknown	APAAPA...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18799
P16403-7-	AAPAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P16403-7-	AAPAAA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16403-7-	AAPAAA...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P16403-11-unknown	AAPPAE...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13999
P16403-12-unknown	APPAEK...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18800
P16403-12-unknown	APPAEK...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17394
P16403-21-unknown	KKKAAK...	21		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14000
P16403-34-unknown	KASGPP...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14001
P16403-34-	KASGPP...	34			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16403-35-	ASGPPV...	35			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16403-36-	SGPPVS...	36			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16403-44-unknown	ITKAVA...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14002
P16403-45-unknown	TKAVAA...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14003
P16403-55-	SGVSLA...	55			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16403-65-unknown	ALAAAG...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14004
P16403-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16403-65-	ALAAAG...	65			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16403-67-unknown	AAAGYD...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14005
P16403-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10002
P16403-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7346
P16403-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14006
P16403-68-unknown	AAGYDV...	68		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5623
P16403-69-unknown	AGYDVE...	69		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14007
P16403-71-unknown	YDVEKN...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14008
P16403-162-	AAATVT...	162			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PAAPAA	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13999
...AAPAAA	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18800
...AAPAAA	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17394
...EKAPVK	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14000
...GGTPRK	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14001
...PVSELI	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14002
...VSELIT	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14003
...AALKKA	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14004
...LKKALA	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14005
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10002
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7346
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14006
...KKALAA	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5623
...KALAAA	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14007
...LAAAGY	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14008
...APKKK	213	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	4	SETA.\|.APAA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	10	APAA.\|.AAPP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	11	PAAA.\|.APPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	11	PAAA.\|.APPA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	20	APVK.\|.KKKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	33	TPRK.\|.KASG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	43	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	44	ELIT.\|.TKAV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	64	LKKA.\|.ALAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	66	KALA.\|.AAAG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATS_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	67	ALAA.\|.AAGY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	68	LAAA.\|.AGYD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	70	AAGY.\|.YDVE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)