P24534: Elongation factor 1-beta

General Information

Protein names	- Elongation factor 1-beta - EF-1-beta
Gene names	EEF1B2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P24534

13 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC HALRWYNHIK
        70         80         90        100        110        120
SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD IDLFGSDDEE ESEEAKRLRE
       130        140        150        160        170        180
ERLAQYESKK AKKPALVAKS SILLDVKPWD DETDMAKLEE CVRSIQADGL VWGSSKLVPV
       190        200        210        220
GYGIKKLQIQ CVVEDDKVGT DMLEEQITAF EDYVQSMDVA AFNKI

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

13 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P24534-2-unknown	GFGDLK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P24534-2-	GFGDLK...	2		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P24534-8-	SPAGLQ...	8		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P24534-11-	GLQVLN...	11		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P24534-11-unknown	GLQVLN...	11		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P24534-103-	LFGSDD...	103		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P24534-103-	LFGSDD...	103		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P24534-103-	LFGSDD...	103		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P24534-103-	LFGSDD...	103		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P24534-103-	LFGSDD...	103		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P24534-103-unknown	LFGSDD...	103		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P24534-108-unknown	DEEESE...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18947
P24534-108-unknown	DEEESE...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17526
P24534-145-unknown	DVKPWD...	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5718
P24534-145-unknown	DVKPWD...	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17527
P24534-146-unknown	VKPWDD...	146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5719
P24534-151-unknown	DETDMA...	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18948
P24534-151-unknown	DETDMA...	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17528
P24534-152-unknown	ETDMAK...	152	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18949
P24534-202-unknown	MLEEQI...	202	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11350

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFGSDD	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18947
...LFGSDD	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17526
...REERLA	123	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407730
...SSILLD	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5718
...SSILLD	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17527
...SILLDV	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5719
...VKPWDD	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18948
...VKPWDD	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17528
...KPWDDE	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18949
...KVGTDM	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11350
...AFNKI	225	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	107	GSDD.\|.DEEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	107	GSDD.\|.DEEE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	144	ILLD.\|.DVKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	144	ILLD.\|.DVKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	145	LLDV.\|.VKPW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	150	PWDD.\|.DETD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	150	PWDD.\|.DETD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	151	WDDE.\|.ETDM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	201	GTDM.\|.MLEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)