P12268: Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}

General Information

Protein names	- Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255\|HAMAP-Rule:MF_03156} - IMP dehydrogenase 2 {ECO:0000255\|HAMAP-Rule:MF_03156} - IMPD 2 {ECO:0000255\|HAMAP-Rule:MF_03156} - IMPDH 2 {ECO:0000255\|HAMAP-Rule:MF_03156} - 1.1.1.205 {ECO:0000255\|HAMAP-Rule:MF_03156} - IMPDH-II
Gene names	IMPDH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12268

16 N-termini

13 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT
        70         80         90        100        110        120
LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV
       130        140        150        160        170        180
LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT
       190        200        210        220        230        240
KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA
       250        260        270        280        290        300
KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI
       310        320        330        340        350        360
GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP
       370        380        390        400        410        420
VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM
       430        440        450        460        470        480
DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR
       490        500        510
AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12268-2-unknown	ADYLIS...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12268-8-unknown	GGTSYV...	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7294
P12268-63-unknown	TPLVSS...	63	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P12268-87-unknown	GIGFIH...	87	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3623
P12268-90-unknown	FIHHNC...	90	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3624
P12268-92-unknown	HHNCTP...	92	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5566
P12268-93-unknown	HNCTPE...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5567
P12268-111-unknown	EQGFIT...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18706
P12268-161-unknown	RDIDFL...	161	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P12268-247-unknown	GAAIGT...	247	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3625
P12268-247-unknown	GAAIGT...	247	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7295
P12268-247-unknown	GAAIGT...	247	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5568
P12268-248-unknown	AAIGTH...	248	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3626
P12268-364-unknown	DGGIQN...	364	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18707
P12268-439-	VAQGVS...	439		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P12268-463-unknown	GIQHSC...	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3627
P12268-463-unknown	GIQHSC...	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5569
P12268-464-unknown	IQHSCQ...	464	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3628
P12268-464-unknown	IQHSCQ...	464	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7296
P12268-466-unknown	HSCQDI...	466	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5570

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DYLISG	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7294
...MALTGG	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3623
...TGGIGF	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3624
...GIGFIH	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5566
...IGFIHH	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5567
...KVKKYE	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18706
...KQLLCG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3625
...KQLLCG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7295
...KQLLCG	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5568
...QLLCGA	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3626
...VPVIAD	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18707
...PYLIAG	462	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3627
...PYLIAG	462	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5569
...YLIAGI	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3628
...YLIAGI	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7296
...IAGIQH	465	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5570
...EKRLF	514	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	7	LISG.\|.GGTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	86	LTGG.\|.GIGF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	89	GIGF.\|.FIHH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	91	GFIH.\|.HHNC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	92	FIHH.\|.HNCT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	110	KKYE.\|.EQGF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	246	LLCG.\|.GAAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	246	LLCG.\|.GAAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	246	LLCG.\|.GAAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	247	LCGA.\|.AAIG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	363	VIAD.\|.DGGI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	462	LIAG.\|.GIQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	462	LIAG.\|.GIQH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	463	IAGI.\|.IQHS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	463	IAGI.\|.IQHS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	465	GIQH.\|.HSCQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

TopFIND

P12268: Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}

General Information

16

N-termini

13

C-termini

16

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

16 N-termini - 13 C-termini - 16 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates