P61604: 10 kDa heat shock protein, mitochondrial

General Information

Protein names	- 10 kDa heat shock protein, mitochondrial - Hsp10 - 10 kDa chaperonin - Chaperonin 10 - CPN10 - Early-pregnancy factor - EPF
Gene names	HSPE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61604

14 N-termini

7 C-termini

8 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG SGSKGKGGEI
70 80 90 100
QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61604-2-unknown	MAGQAF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61604-2-unknown	MAGQAF...	1		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16791
P61604-2-Acetylation	AGQAFR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61604-19-unknown	ERSAAE...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7618
P61604-20-unknown	RSAAET...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7619
P61604-20-unknown	RSAAET...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6087
P61604-21-unknown	SAAETV...	21			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61604-21-unknown	SAAETV...	21			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61604-21-	SAAETV...	21			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P61604-21-	SAAETV...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P61604-21-	SAAETV...	21			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P61604-21-	SAAETV...	21			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P61604-21-	SAAETV...	21			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P61604-29-unknown	GGIMLP...	29			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61604-29-unknown	GGIMLP...	29		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61604-29-unknown	GGIMLP...	29		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P61604-29-	GGIMLP...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P61604-32-unknown	MLPEKS...	32			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61604-44-unknown	ATVVAV...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19238
P61604-45-	TVVAVG...	45			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P61604-45-	TVVAVG...	45			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P61604-48-	AVGSGS...	48			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P61604-51-unknown	SGSKGK...	51		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7620
P61604-84-unknown	DDKDYF...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19239
P61604-84-unknown	DDKDYF...	84		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17765

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DRVLVE	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7618
...RVLVER	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7619
...RVLVER	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6087
...GKVLQA	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19238
...VVAVGS	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7620
...TKVVLD	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19239
...TKVVLD	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17765
...GKYVD	102		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GKYVD	102		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GKYVD	102	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GKYVD	102		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GKYVD	102		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MAP12_HUMAN	1	.\|.AGQA	inferred from experiment	unknown	MEROPS		Merops MAP12_HUMAN -> CH10_HUMAN @1
CATS_HUMAN	18	VLVE.\|.ERSA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	19	LVER.\|.RSAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	19	LVER.\|.RSAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	43	VLQA.\|.ATVV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	50	AVGS.\|.SGSK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	83	VVLD.\|.DDKD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	83	VVLD.\|.DDKD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)