O60749: Sorting nexin-2

General Information

Protein names	- Sorting nexin-2 - Transformation-related gene 9 protein - TRG-9
Gene names	SNX2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60749

13 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAEREPPPL GDGKPTDFED LEDGEDLFTS TVSTLESSPS SPEPASLPAE DISANSNGPK
        70         80         90        100        110        120
PTEVVLDDDR EDLFAEATEE VSLDSPEREP ILSSEPSPAV TPVTPTTLIA PRIESKSMSA
       130        140        150        160        170        180
PVIFDRSREE IEEEANGDIF DIEIGVSDPE KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV
       190        200        210        220        230        240
KRRFSDFLGL HSKLASKYLH VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE
       250        260        270        280        290        300
RYLQRTVKHP TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN
       310        320        330        340        350        360
ESDAWFEEKQ QQFENLDQQL RKLHVSVEAL VCHRKELSAN TAAFAKSAAM LGNSEDHTAL
       370        380        390        400        410        420
SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI AAVKGVFDHR MKCWQKWEDA
       430        440        450        460        470        480
QITLLKKREA EAKMMVANKP DKIQQAKNEI REWEAKVQQG ERDFEQISKT IRKEVGRFEK
       490        500        510
ERVKDFKTVI IKYLESLVQT QQQLIKYWEA FLPEAKAIA

Isoforms

- Isoform 2 of Sorting nexin-2

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60749-1-unknown	MAAERE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60749-88-	REPILS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60749-88-	REPILS...	88		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60749-117-	SMSAPV...	117		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60749-118-unknown	MSAPVI...	118	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90189
O60749-118-unknown	MSAPVI...	118	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421663
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60749-119-	SAPVIF...	119		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60749-119-unknown	SAPVIF...	119	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168304
O60749-273-unknown	TQALSG...	273	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18292
O60749-273-unknown	TQALSG...	273	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144988
O60749-347-	SAAMLG...	347		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60749-347-	SAAMLG...	347		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60749-347-	SAAMLG...	347		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60749-347-unknown	SAAMLG...	347	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172363
O60749-352-unknown	GNSEDH...	352	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7046
O60749-352-unknown	GNSEDH...	352	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147927
O60749-353-unknown	NSEDHT...	353	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5206
O60749-353-unknown	NSEDHT...	353	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7048
O60749-353-unknown	NSEDHT...	353	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147946
O60749-434-unknown	MMVANK...	434	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172365
O60749-434-	MMVANK...	434		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LESSEL	266	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422413
...LESSEL	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113810
...PRAVNT	272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18292
...PRAVNT	272	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128268
...SAAMLG	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7046
...SAAMLG	351	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131288
...AAMLGN	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5206
...AAMLGN	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7048
...AAMLGN	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131307
...AKAIA	519	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AKAIA	519	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85807

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	272	AVNT.\|.TQAL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	351	AMLG.\|.GNSE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	352	MLGN.\|.NSED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	352	MLGN.\|.NSED	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)