O94826: Mitochondrial import receptor subunit TOM70

General Information

Protein names	- Mitochondrial import receptor subunit TOM70 - Mitochondrial precursor proteins import receptor - Translocase of outer membrane 70 kDa subunit - Translocase of outer mitochondrial membrane protein 70 {ECO:0000312\|HGNC:HGNC:11985}
Gene names	TOMM70A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O94826

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS
        70         80         90        100        110        120
RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK
       130        140        150        160        170        180
GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV
       190        200        210        220        230        240
ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA
       250        260        270        280        290        300
KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK
       310        320        330        340        350        360
AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE
       370        380        390        400        410        420
ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA
       430        440        450        460        470        480
VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA
       490        500        510        520        530        540
LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI
       550        560        570        580        590        600
DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK

YGLKPPTL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O94826-2-unknown	MAASKP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94826-2-Acetylation	AASKPV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94826-2-Acetylation	AASKPV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O94826-14-	AAVPSS...	14			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94826-14-	AAVPSS...	14			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O94826-15-	AVPSSG...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O94826-15-	AVPSSG...	15			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O94826-21-	SGVGGG...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O94826-21-	SGVGGG...	21			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94826-21-	SGVGGG...	21			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O94826-303-	QYMEEE...	303			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94826-485-	ALTDQQ...	485			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O94826-485-	ALTDQQ...	485			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O94826-589-unknown	DAAHAQ...	589		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18324

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LYSLCD	588	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18324
	...KPPTL	608	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	588	SLCD.\|.DAAH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)