P00338: L-lactate dehydrogenase A chain

General Information

Protein names	- L-lactate dehydrogenase A chain - LDH-A - 1.1.1.27 - Cell proliferation-inducing gene 19 protein - LDH muscle subunit - LDH-M - Renal carcinoma antigen NY-REN-59
Gene names	LDHA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00338

11 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of L-lactate dehydrogenase A chain - Isoform 3 of L-lactate dehydrogenase A chain - Isoform 4 of L-lactate dehydrogenase A chain - Isoform 5 of L-lactate dehydrogenase A chain

Sequence View

        10         20         30         40         50         60
MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
        70         80         90        100        110        120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
       130        140        150        160        170        180
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
       190        200        210        220        230        240
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE
       250        260        270        280        290        300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
       310        320        330
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF         10         20         30         40         50         60
MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
        70         80         90        100        110        120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
       130        140        150        160        170        180
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
       190        200        210        220        230        240
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE
       250        260        270        280        290        300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
       310        320        330
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF         10         20         30         40         50         60
MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
        70         80         90        100        110        120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
       130        140        150        160        170        180
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
       190        200        210        220        230        240
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE
       250        260        270        280        290        300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
       310        320        330
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF         10         20         30         40         50         60
MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG
        70         80         90        100        110        120
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
       130        140        150        160        170        180
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
       190        200        210        220        230        240
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE
       250        260        270        280        290        300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI
       310        320        330
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00338-1-unknown	MATLKD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79472
P00338-1-unknown	MATLKD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79474
P00338-1-unknown	MATLKD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79475
P00338-1-unknown	MATLKD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102255
P00338-2-unknown	MATLKD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00338-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00338-2-Acetylation	ATLKDQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P00338-2-Acetylation	ATLKDQ...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00338-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111146
P00338-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111147
P00338-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111149
P00338-2-Acetylation	ATLKDQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111148
P00338-158-unknown	VIGSGC...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181121
P00338-158-unknown	VIGSGC...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181120
P00338-158-unknown	VIGSGC...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181123
P00338-158-unknown	VIGSGC...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181122
P00338-158-	VIGSGC...	158			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00338-197-	SVPVWS...	197			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P00338-197-unknown	SVPVWS...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176545
P00338-197-unknown	SVPVWS...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176544
P00338-197-unknown	SVPVWS...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176547
P00338-197-unknown	SVPVWS...	197		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176546
P00338-218-unknown	LGTDKD...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16979
P00338-218-unknown	LGTDKD...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18334
P00338-218-unknown	LGTDKD...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145132
P00338-218-unknown	LGTDKD...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148321
P00338-256-unknown	VADLAE...	256		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7086
P00338-256-unknown	VADLAE...	256		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146525
P00338-256-unknown	VADLAE...	256		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149475
P00338-319-	SADTLW...	319			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P00338-319-unknown	SADTLW...	319		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176272
P00338-319-unknown	SADTLW...	319		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176273
P00338-319-unknown	SADTLW...	319		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00338-319-unknown	SADTLW...	319		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TLHPDL	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16979
...TLHPDL	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18334
...TLHPDL	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128418
...TLHPDL	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130608
...TLHPDL	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130609
...TLHPDL	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131691
...AIGLSV	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7086
...AIGLSV	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129833
...AIGLSV	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132859
...KELQF	332	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KELQF	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75092
...KELQF	332	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75091

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	217	HPDL.\|.LGTD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	217	HPDL.\|.LGTD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	255	GLSV.\|.VADL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)