Q14974: Importin subunit beta-1

General Information

Protein names	- Importin subunit beta-1 - Importin-90 - Karyopherin subunit beta-1 - Nuclear factor p97 - Pore targeting complex 97 kDa subunit - PTAC97
Gene names	KPNB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14974

13 N-termini

13 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ
        70         80         90        100        110        120
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE
       130        140        150        160        170        180
IPVNQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG
       190        200        210        220        230        240
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN
       250        260        270        280        290        300
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
       310        320        330        340        350        360
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE
       370        380        390        400        410        420
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS QLKPLVIQAM PTLIELMKDP
       430        440        450        460        470        480
SVVVRDTAAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA
       490        500        510        520        530        540
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA
       550        560        570        580        590        600
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
       610        620        630        640        650        660
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN
       670        680        690        700        710        720
YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI
       730        740        750        760        770        780
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ
       790        800        810        820        830        840
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR
       850        860        870
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Isoforms

- Isoform 2 of Importin subunit beta-1

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

13 N-termini - 13 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14974-1-	MELITI...	1			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14974-1-Acetylation	MELITI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14974-1-Acetylation	MELITI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14974-1-Acetylation	MELITI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q14974-1-Acetylation	MELITI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14974-1-Acetylation	MELITI...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14974-64-	SLTSKD...	64			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14974-64-	SLTSKD...	64			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14974-129-acetylation	LIPQLV...	129	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q14974-139-unknown	NPNSTE...	139		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6408
Q14974-139-unknown	NPNSTE...	139		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7844
Q14974-146-unknown	MKESTL...	146		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77841
Q14974-146-unknown	MKESTL...	146		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438253
Q14974-146-unknown	MKESTL...	146		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464200
Q14974-146-unknown	MKESTL...	146		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438964
Q14974-146-unknown	MKESTL...	146		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445006
Q14974-195-unknown	TNALLN...	195		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4058
Q14974-195-unknown	TNALLN...	195		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139215
Q14974-513-unknown	TTDRPD...	513		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6409
Q14974-513-unknown	TTDRPD...	513		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7845
Q14974-513-unknown	TTDRPD...	513		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151361
Q14974-515-unknown	DRPDGH...	515		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19534
Q14974-515-unknown	DRPDGH...	515		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151409
Q14974-628-unknown	ALMAVS...	628		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12294
Q14974-628-unknown	ALMAVS...	628		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153226
Q14974-699-unknown	NLGNEN...	699		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7847
Q14974-699-unknown	NLGNEN...	699		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154029
Q14974-741-unknown	QASQAQ...	741		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6411
Q14974-741-unknown	QASQAQ...	741		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7849
Q14974-741-unknown	QASQAQ...	741		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154534
Q14974-787-unknown	VMLVQP...	787		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12296
Q14974-787-unknown	VMLVQP...	787		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155215

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VANVTN	138	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6408
...VANVTN	138	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7844
...EHMKES	148	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464042
...VKLAAT	194	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4058
...VKLAAT	194	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt122290
...SLEFTK	205	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464200
...SLEFTK	205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt108692
...QKLLET	512	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6409
...QKLLET	512	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7845
...QKLLET	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134763
...LLETTD	514	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19534
...LLETTD	514	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134812
...CATLQN	589	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463190
...CATLQN	589	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt108694
...GVQEDA	627	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12294
...GVQEDA	627	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136651
...QLLLEN	698	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7847
...QLLLEN	698	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137448
...LNTLQQ	740	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6411
...LNTLQQ	740	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7849
...LNTLQQ	740	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137956
...NVHPDV	786	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12296
...NVHPDV	786	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138646
...LKNQA	876	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LKNQA	876	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt73459
...LKNQA	876		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LKNQA	876		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LKNQA	876		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LKNQA	876		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	138	NVTN.\|.NPNS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	138	NVTN.\|.NPNS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	194	LAAT.\|.TNAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	512	LLET.\|.TTDR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	512	LLET.\|.TTDR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	514	ETTD.\|.DRPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	627	QEDA.\|.ALMA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	698	LLEN.\|.NLGN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	740	TLQQ.\|.QASQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	740	TLQQ.\|.QASQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	786	HPDV.\|.VMLV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)