P05783: Keratin, type I cytoskeletal 18

General Information

Protein names	- Keratin, type I cytoskeletal 18 - Cell proliferation-inducing gene 46 protein - Cytokeratin-18 - CK-18 - Keratin-18 - K18
Gene names	KRT18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05783

7 N-termini

6 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS
        70         80         90        100        110        120
GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG
       130        140        150        160        170        180
PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN
       190        200        210        220        230        240
DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP
       250        260        270        280        290        300
KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR
       310        320        330        340        350        360
RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA
       370        380        390        400        410        420
QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS
       430
ETNDTKVLRH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P05783-2-unknown	MSFTTR...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05783-2-Acetylation	SFTTRS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05783-114-unknown	EHLEKK...	114		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18484
P05783-114-unknown	EHLEKK...	114		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17120
P05783-239-unknown	APKSQD...	239		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1568
P05783-239-unknown	APKSQD...	239		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2460
P05783-239-unknown	APKSQD...	239		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2788
P05783-394-unknown	DALDSS...	394		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18485
P05783-395-unknown	ALDSSN...	395		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11051
P05783-398-unknown	SSNSMQ...	398		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1569
P05783-398-unknown	SSNSMQ...	398		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2789

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ESKIRE	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18484
...ESKIRE	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17120
...TVEVDA	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1568
...TVEVDA	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2460
...TVEVDA	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2788
...DFNLGD	393	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18485
...FNLGDA	394	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11051
...GDALDS	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1569
...GDALDS	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2789
...KVLRH	430	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	113	KIRE.\|.EHLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	113	KIRE.\|.EHLE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	238	EVDA.\|.APKS	inferred from experiment	unknown	MEROPS	Omary MB	Ku NO et al.:Apoptosis generates stable frag... (C14.003)	9407108,
CASP6_HUMAN	238	EVDA.\|.APKS	inferred from experiment	unknown	MEROPS	Oshima RG	Caulin C et al.:Caspase cleavage of keratin 18 ... (C14.005)	9298992,
CASP7_HUMAN	238	EVDA.\|.APKS	inferred from experiment	unknown	MEROPS	Oshima RG	Caulin C et al.:Caspase cleavage of keratin 18 ... (C14.005)	9298992,
MEP1B_HUMAN	393	NLGD.\|.DALD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	394	LGDA.\|.ALDS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	397	ALDS.\|.SSNS	inferred from experiment	unknown	MEROPS	Cohen GM	MacFarlane M et al.:Active caspases and cleaved cyt... (C14.003)	10725337,
CASP7_HUMAN	397	ALDS.\|.SSNS	inferred from experiment	unknown	MEROPS	Cohen GM	MacFarlane M et al.:Active caspases and cleaved cyt... (C14.003)	10725337,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)