P12277: Creatine kinase B-type {ECO:0000305}

General Information

Protein names	- Creatine kinase B-type {ECO:0000305} - 2.7.3.2 - Brain creatine kinase {ECO:0000303\|PubMed:2828370} - B-CK - Creatine kinase B chain {ECO:0000303\|PubMed:3692484} - Creatine phosphokinase B-type - CPK-B
Gene names	CKB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12277

17 N-termini

18 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG
        70         80         90        100        110        120
VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD
       130        140        150        160        170        180
LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT
       190        200        210        220        230        240
EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM
       250        260        270        280        290        300
QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
       310        320        330        340        350        360
NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL
       370        380
IEMEQRLEQG QAIDDLMPAQ K

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12277-2-unknown	PFSNSH...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12277-12-unknown	LRFPAE...	12	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5571
P12277-19-unknown	EFPDLS...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18711
P12277-20-unknown	FPDLSA...	20	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18712
P12277-30-unknown	MAKVLT...	30	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451611
P12277-59-unknown	TGVDNP...	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7297
P12277-59-unknown	TGVDNP...	59	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5572
P12277-74-unknown	CVAGDE...	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7298
P12277-77-unknown	GDEESY...	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5573
P12277-99-unknown	GYKPSD...	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5574
P12277-161-unknown	ALSSLD...	161	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5575
P12277-178-	SMTEAE...	178		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P12277-192-unknown	FLFDKP...	192	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451426
P12277-227-unknown	VWVNEE...	227	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5576
P12277-239-unknown	SMQKGG...	239	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5577
P12277-259-unknown	QIETLF...	259	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5578
P12277-332-unknown	GVFDVS...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3632
P12277-332-unknown	GVFDVS...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7299
P12277-332-unknown	GVFDVS...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5579
P12277-371-unknown	QAIDDL...	371	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7300

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HNALKL	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5571
...FPAEDE	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18711
...PAEDEF	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18712
...DDVIQT	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7297
...DDVIQT	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5572
...IMTVGC	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7298
...VGCVAG	76	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5573
...EDRHGG	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5574
...AIEKLA	157	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451611
...KLAVEA	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5575
...DARGIW	217	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451904
...NKTFLV	226	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5576
...HLRVIS	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5577
...CTGLTQ	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5578
...TAAVGG	331	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3632
...TAAVGG	331	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7299
...TAAVGG	331	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5579
...DVSNAD	339	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451686
...RLEQGQ	370	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7300
...MPAQK	381		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MPAQK	381		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...MPAQK	381	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...MPAQK	381		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...MPAQK	381		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	11	ALKL.\|.LRFP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	18	AEDE.\|.EFPD	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	19	EDEF.\|.FPDL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	58	VIQT.\|.TGVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	58	VIQT.\|.TGVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	73	TVGC.\|.CVAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	76	CVAG.\|.GDEE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	98	RHGG.\|.GYKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	160	AVEA.\|.ALSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	226	TFLV.\|.VWVN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	238	RVIS.\|.SMQK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	258	GLTQ.\|.QIET	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	331	AVGG.\|.GVFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	331	AVGG.\|.GVFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	331	AVGG.\|.GVFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	370	EQGQ.\|.QAID	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

TopFIND

P12277: Creatine kinase B-type {ECO:0000305}

General Information

17

N-termini

18

C-termini

16

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 18 C-termini - 16 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates