P35659: Protein DEK

General Information

Protein names	- Protein DEK
Gene names	DEK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35659

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK
        70         80         90        100        110        120
KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV
       130        140        150        160        170        180
SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL
       190        200        210        220        230        240
NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK
       250        260        270        280        290        300
EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE
       310        320        330        340        350        360
SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT
       370
ERKDFIKTTV KELIS

Isoforms

- Isoform 2 of Protein DEK

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P35659-2-unknown	MSASAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35659-1-unknown	MSASAP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72580
P35659-2-Acetylation	SASAPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P35659-2-Acetylation	SASAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P35659-2-Acetylation	SASAPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P35659-2-Acetylation	SASAPA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111241
P35659-12-	GTPTQP...	12			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P35659-12-unknown	GTPTQP...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165397
P35659-46-unknown	EEKEKS...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19080
P35659-68-	MQVSSL...	68			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P35659-68-	MQVSSL...	68			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P35659-68-	MQVSSL...	68			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P35659-126-unknown	NVGQFS...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176621
P35659-126-	NVGQFS...	126			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EEEEEE	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19080
...EEEEEE	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153851
...KELIS	375	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KELIS	375	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68198

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	45	EEEE.\|.EEKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)