P62753: 40S ribosomal protein S6 {ECO:0000303|PubMed:29563586}

General Information

Protein names	- 40S ribosomal protein S6 {ECO:0000303\|PubMed:29563586} - Phosphoprotein NP33 - Small ribosomal subunit protein eS6 {ECO:0000303\|PubMed:24524803}
Gene names	RPS6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62753

18 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG
        70         80         90        100        110        120
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD
       130        140        150        160        170        180
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV
       190        200        210        220        230        240
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS

TSKSESSQK

Isoforms

Sequence View

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Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62753-1-unknown	MKLNIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62753-1-unknown	MKLNIS...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62753-1-unknown	MKLNIS...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62753-1-unknown	MKLNIS...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62753-6-unknown	SFPATG...	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14260
P62753-12-unknown	CQKLIE...	12	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11776
P62753-32-unknown	MATEVA...	32	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000369745
P62753-32-unknown	MATEVA...	32	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000369743
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62753-32-	MATEVA...	32		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62753-33-	ATEVAA...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62753-33-	ATEVAA...	33		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62753-39-unknown	DALGEE...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19265
P62753-39-unknown	DALGEE...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17791
P62753-59-	QGFPMK...	59		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62753-106-unknown	LSVLNL...	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11777
P62753-110-unknown	NLVIVK...	110	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14261
P62753-143-	KLFNLS...	143		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62753-144-	LFNLSK...	144		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62753-145-unknown	FNLSKE...	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14262
P62753-145-unknown	FNLSKE...	145		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62753-145-	FNLSKE...	145		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62753-163-unknown	NKEGKK...	163	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14263
P62753-184-unknown	VLQHKR...	184	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10136
P62753-209-unknown	YAKLLA...	209	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14264
P62753-218-unknown	KEAKEK...	218	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14265

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...MKLNIS	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14260
...FPATGC	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11776
...TEVAAD	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19265
...TEVAAD	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17791
...IVDANL	105	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11777
...NLSVLN	109	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14261
...RIRKLF	144	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14262
...VRKPLN	162	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14263
...LVTPRV	183	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10136
...EEAAEY	208	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14264
...LAKRMK	217	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14265
...ESSQK	249		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESSQK	249		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ESSQK	249	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ESSQK	249		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESSQK	249		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	LNIS.\|.SFPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	11	ATGC.\|.CQKL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	38	VAAD.\|.DALG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	38	VAAD.\|.DALG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	105	DANL.\|.LSVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	109	SVLN.\|.NLVI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	144	RKLF.\|.FNLS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	162	KPLN.\|.NKEG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	183	TPRV.\|.VLQH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	208	AAEY.\|.YAKL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	217	KRMK.\|.KEAK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)