Q15691: Microtubule-associated protein RP/EB family member 1

General Information

Protein names	- Microtubule-associated protein RP/EB family member 1 - APC-binding protein EB1 - End-binding protein 1 - EB1
Gene names	MAPRE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15691

18 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK
        70         80         90        100        110        120
VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD
       130        140        150        160        170        180
GKDYDPVAAR QGQETAVAPS LVAPALNKPK KPLTSSSAAP QRPISTQRTA AAPKAGPGVV
       190        200        210        220        230        240
RKNPGVGNGD DEAAELMQQV NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ
       250        260
RIVDILYATD EGFVIPDEGG PQEEQEEY

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15691-2-unknown	MAVNVY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15691-2-Acetylation	AVNVYS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15691-2-Acetylation	AVNVYS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15691-2-Acetylation	AVNVYS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15691-2-Acetylation	AVNVYS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15691-2-Acetylation	AVNVYS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15691-7-	STSVTS...	7			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15691-7-	STSVTS...	7			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15691-7-unknown	STSVTS...	7			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15691-7-unknown	STSVTS...	7			unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q15691-117-	ANYDGK...	117			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15691-137-unknown	VAPSLV...	137		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4113
Q15691-142-unknown	VAPALN...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4114
Q15691-143-unknown	APALNK...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6480
Q15691-143-unknown	APALNK...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7868
Q15691-151-	KPLTSS...	151			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15691-151-	KPLTSS...	151			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15691-151-unknown	KPLTSS...	151			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15691-155-unknown	SSSAAP...	155		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7869
Q15691-157-	SAAPQR...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15691-169-	TAAAPK...	169			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15691-169-	TAAAPK...	169			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15691-169-unknown	TAAAPK...	169			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15691-182-	KNPGVG...	182			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15691-193-unknown	AAELMQ...	193		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19587
Q15691-194-unknown	AELMQQ...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19588
Q15691-251-unknown	EGFVIP...	251		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12371

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GQETAV	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4113
...VAPSLV	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4114
...APSLVA	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6480
...APSLVA	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7868
...KKPLTS	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7869
...NGDDEA	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19587
...GDDEAA	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19588
...LYATDE	250	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12371
...EQEEY	268	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	136	ETAV.\|.VAPS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	141	PSLV.\|.VAPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	142	SLVA.\|.APAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	142	SLVA.\|.APAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	154	PLTS.\|.SSSA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	192	DDEA.\|.AAEL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	193	DEAA.\|.AELM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	250	ATDE.\|.EGFV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)