P68371: Tubulin beta-4B chain

General Information

Protein names	- Tubulin beta-4B chain - Tubulin beta-2 chain - Tubulin beta-2C chain
Gene names	TUBB4B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P68371

25 N-termini

19 C-termini

22 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV
        70         80         90        100        110        120
PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
       130        140        150        160        170        180
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV
       190        200        210        220        230        240
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
       250        260        270        280        290        300
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM
       310        320        330        340        350        360
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
       370        380        390        400        410        420
LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
       430        440
EYQQYQDATA EEEGEFEEEA EEEVA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

25 N-termini - 19 C-termini - 22 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P68371-1-unknown	MREIVH...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P68371-1-	MREIVH...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-7-unknown	LQAGQC...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7680
P68371-7-unknown	LQAGQC...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6165
P68371-7-unknown	LQAGQC...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19292
P68371-26-unknown	DEHGID...	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7681
P68371-38-unknown	GDSDLQ...	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6166
P68371-63-	AVLVDL...	63		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-67-unknown	DLEPGT...	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15377
P68371-102-unknown	AKGHYT...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15378
P68371-102-unknown	AKGHYT...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11823
P68371-104-	GHYTEG...	104		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-108-unknown	EGAELV...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15379
P68371-115-unknown	SVLDVV...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7682
P68371-115-unknown	SVLDVV...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11824
P68371-136-unknown	THSLGG...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15380
P68371-138-	SLGGGT...	138		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-140-unknown	GGGTGS...	140	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15381
P68371-141-unknown	GGTGSG...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7683
P68371-166-	TFSVVP...	166		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-206-unknown	ALYDIC...	206	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11825
P68371-218-unknown	TTPTYG...	218	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15382
P68371-222-unknown	YGDLNH...	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15383
P68371-230-unknown	SATMSG...	230	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15384
P68371-241-unknown	RFPGQL...	241	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15385
P68371-252-unknown	KLAVNM...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10163
P68371-254-unknown	AVNMVP...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15386
P68371-254-	AVNMVP...	254		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P68371-264-unknown	HFFMPG...	264	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15387

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...REIVHL	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7680
...REIVHL	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6165
...REIVHL	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19292
...WEVISD	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7681
...TGTYHG	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6166
...RAVLVD	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15377
...AGNNWA	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15378
...AGNNWA	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11823
...KGHYTE	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15379
...AELVDS	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7682
...AELVDS	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11824
...QGFQLT	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15380
...LTHSLG	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15381
...THSLGG	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7683
...CIDNEA	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11825
...RTLKLT	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15382
...LTTPTY	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15383
...LNHLVS	229	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15384
...VTTCLR	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15385
...NADLRK	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10163
...DLRKLA	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15386
...PFPRLH	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15387
...EEEVA	445	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	6	IVHL.\|.LQAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	6	IVHL.\|.LQAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	6	IVHL.\|.LQAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	25	VISD.\|.DEHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	37	TYHG.\|.GDSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
HTRA2_HUMAN	66	VLVD.\|.DLEP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	101	NNWA.\|.AKGH	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	101	NNWA.\|.AKGH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	107	HYTE.\|.EGAE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATS_HUMAN	114	LVDS.\|.SVLD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	114	LVDS.\|.SVLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	135	FQLT.\|.THSL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	139	HSLG.\|.GGGT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATS_HUMAN	140	SLGG.\|.GGTG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	205	DNEA.\|.ALYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	217	LKLT.\|.TTPT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	221	TPTY.\|.YGDL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	229	HLVS.\|.SATM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	240	TCLR.\|.RFPG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	251	DLRK.\|.KLAV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	253	RKLA.\|.AVNM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	263	PRLH.\|.HFFM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)