P30153: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Medium tumor antigen-associated 61 kDa protein - PP2A subunit A isoform PR65-alpha - PP2A subunit A isoform R1-alpha
Gene names	PPP2R1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30153

16 N-termini

11 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY
        70         80         90        100        110        120
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS
       130        140        150        160        170        180
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM
       190        200        210        220        230        240
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL
       250        260        270        280        290        300
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA
       310        320        330        340        350        360
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN
       370        380        390        400        410        420
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR
       430        440        450        460        470        480
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA
       490        500        510        520        530        540
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV
       550        560        570        580
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 11 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30153-2-unknown	MAAADG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30153-2-Acetylation	AAADGD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30153-2-Acetylation	AAADGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P30153-2-Acetylation	AAADGD...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P30153-2-Acetylation	AAADGD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P30153-2-Acetylation	AAADGD...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30153-111-unknown	SLRAIS...	111		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P30153-114-	AISHEH...	114			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30153-114-	AISHEH...	114			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30153-114-	AISHEH...	114			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P30153-114-	AISHEH...	114			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30153-117-unknown	HEHSPS...	117		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5773
P30153-123-unknown	DLEAHF...	123		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19026
P30153-126-unknown	AHFVPL...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7416
P30153-172-acetylation	NLCSDD...	172	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30153-180-unknown	MVRRAA...	180		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470504
P30153-219-unknown	SVRLLA...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1777
P30153-479-unknown	HATIIP...	479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7417
P30153-489-unknown	MSGDPN...	489		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5774
P30153-490-unknown	SGDPNY...	490		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5775
P30153-509-unknown	SEVCGQ...	509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5776
P30153-528-acetylation	MAGDPV...	528	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P30153-547-unknown	IGPILD...	547		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14074

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRAISH	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5773
...EHSPSD	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19026
...PSDLEA	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7416
...SDEQDS	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1777
...GLSPIL	355	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391905
...GKEWAH	478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7417
...PKVLAM	488	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5774
...KVLAMS	489	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5775
...CINVLS	508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5776
...KSLQKI	546	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14074
...VLSLA	589	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	116	AISH.\|.HEHS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	122	SPSD.\|.DLEA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	125	DLEA.\|.AHFV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	218	EQDS.\|.SVRL	inferred from experiment	unknown	MEROPS	Giegel DA	Santoro MF et al.:Regulation of protein phosphata... (C14.003)	9582351,
CATS_HUMAN	478	EWAH.\|.HATI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	488	VLAM.\|.MSGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	489	LAMS.\|.SGDP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	508	NVLS.\|.SEVC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	546	LQKI.\|.IGPI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)