Q96DI7: U5 small nuclear ribonucleoprotein 40 kDa protein

General Information

Protein names	- U5 small nuclear ribonucleoprotein 40 kDa protein - U5 snRNP 40 kDa protein - U5-40K - 38 kDa-splicing factor - Prp8-binding protein - hPRP8BP - U5 snRNP-specific 40 kDa protein - WD repeat-containing protein 57
Gene names	SNRNP40
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96DI7

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP RCSSLQAPIM
        70         80         90        100        110        120
LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD NYATLKGHSG AVMELHYNTD
       130        140        150        160        170        180
GSMLFSASTD KTVAVWDSET GERVKRLKGH TSFVNSCYPA RRGPQLVCTG SDDGTVKLWD
       190        200        210        220        230        240
IRKKAAIQTF QNTYQVLAVT FNDTSDQIIS GGIDNDIKVW DLRQNKLTYT MRGHADSVTG
       250        260        270        280        290        300
LSLSSEGSYL LSNAMDNTVR VWDVRPFAPK ERCVKIFQGN VHNFEKNLLR CSWSPDGSKI
       310        320        330        340        350
AAGSADRFVY VWDTTSRRIL YKLPGHAGSI NEVAFHPDEP IIISASSDKR LYMGEIQ

Isoforms

- Isoform 2 of U5 small nuclear ribonucleoprotein 40 kDa protein

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96DI7-1-unknown	MIEQQK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96DI7-1-unknown	MIEQQK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96DI7-1-acetylation	MIEQQK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96DI7-8-unknown	KGPELP...	8			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96DI7-8-	KGPELP...	8			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96DI7-27-	GAGSGP...	27			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96DI7-39-	ATPGAL...	39			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96DI7-279-unknown	GNVHNF...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8018
Q96DI7-339-unknown	EPIIIS...	339		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19737

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VKIFQG	278	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8018
...AFHPDE	338	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19737
...MGEIQ	357	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...MGEIQ	357		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	278	IFQG.\|.GNVH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	338	HPDE.\|.EPII	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)