Q9UBT2: SUMO-activating enzyme subunit 2

General Information

Protein names	- SUMO-activating enzyme subunit 2 - 2.3.2.- - Anthracycline-associated resistance ARX - Ubiquitin-like 1-activating enzyme E1B - Ubiquitin-like modifier-activating enzyme 2
Gene names	UBA2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UBT2

9 N-termini

10 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALSRGLPRE LAEAVAGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ
        70         80         90        100        110        120
FLFQKKHVGR SKAQVAKESV LQFYPKANIV AYHDSIMNPD YNVEFFRQFI LVMNALDNRA
       130        140        150        160        170        180
ARNHVNRMCL AADVPLIESG TAGYLGQVTT IKKGVTECYE CHPKPTQRTF PGCTIRNTPS
       190        200        210        220        230        240
EPIHCIVWAK YLFNQLFGEE DADQEVSPDR ADPEAAWEPT EAEARARASN EDGDIKRIST
       250        260        270        280        290        300
KEWAKSTGYD PVKLFTKLFK DDIRYLLTMD KLWRKRKPPV PLDWAEVQSQ GEETNASDQQ
       310        320        330        340        350        360
NEPQLGLKDQ QVLDVKSYAR LFSKSIETLR VHLAEKGDGA ELIWDKDDPS AMDFVTSAAN
       370        380        390        400        410        420
LRMHIFSMNM KSRFDIKSMA GNIIPAIATT NAVIAGLIVL EGLKILSGKI DQCRTIFLNK
       430        440        450        460        470        480
QPNPRKKLLV PCALDPPNPN CYVCASKPEV TVRLNVHKVT VLTLQDKIVK EKFAMVAPDV
       490        500        510        520        530        540
QIEDGKGTIL ISSEEGETEA NNHKKLSEFG IRNGSRLQAD DFLQDYTLLI NILHSEDLGK
       550        560        570        580        590        600
DVEFEVVGDA PEKVGPKQAE DAAKSITNGS DDGAQPSTST AQEQDDVLIV DSDEEDSSNN
       610        620        630        640
ADVSEEERSR KRKLDEKENL SAKRSRIEQK EELDDVIALD

Isoforms

- Isoform 2 of SUMO-activating enzyme subunit 2

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 10 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UBT2-1-unknown	MALSRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UBT2-24-unknown	GAGGIG...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8128
Q9UBT2-97-unknown	MNPDYN...	97	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437484
Q9UBT2-144-unknown	YLGQVT...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4276
Q9UBT2-146-unknown	GQVTTI...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6834
Q9UBT2-181-unknown	EPIHCI...	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19832
Q9UBT2-445-unknown	ASKPEV...	445	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8129
Q9UBT2-446-unknown	SKPEVT...	446	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8130
Q9UBT2-475-unknown	MVAPDV...	475	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475656

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RVLVVG	23	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8128
...SGTAGY	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4276
...TAGYLG	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6834
...RNTPSE	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19832
...EVQSQG	290	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467433
...NCYVCA	444	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8129
...CYVCAS	445	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8130
...YTLLIN	530	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468756
...VIALD	640	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VIALD	640		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VIALD	640		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	23	LVVG.\|.GAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	143	TAGY.\|.YLGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	145	GYLG.\|.GQVT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	180	TPSE.\|.EPIH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	444	YVCA.\|.ASKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	445	VCAS.\|.SKPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)