P16949: Stathmin

General Information

Protein names	- Stathmin - Leukemia-associated phosphoprotein p18 - Metablastin - Oncoprotein 18 - Op18 - Phosphoprotein p19 - pp19 - Prosolin - Protein Pr22 - pp17
Gene names	STMN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P16949

31 N-termini

6 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER
        70         80         90        100        110        120
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL
       130        140
ERLREKDKHI EEVRKNKESK DPADETEAD

Isoforms

- Isoform 2 of Stathmin

Sequence View

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Protein Neighborhood

Domains & Features

31 N-termini - 6 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P16949-1-unknown	MASSDI...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90942
P16949-2-unknown	MASSDI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16949-1-acetylation	MASSDI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P16949-1-acetylation	MASSDI...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163007
P16949-2-Acetylation	ASSDIQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P16949-2-Acetylation	ASSDIQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P16949-2-Acetylation	ASSDIQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P16949-2-Acetylation	ASSDIQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P16949-2-Acetylation	ASSDIQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110737
P16949-5-unknown	DIQVKE...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18801
P16949-5-unknown	DIQVKE...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17397
P16949-5-unknown	DIQVKE...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194661
P16949-19-unknown	AFELIL...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164205
P16949-19-	AFELIL...	19			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16949-19-	AFELIL...	19			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-19-	AFELIL...	19			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16949-19-	AFELIL...	19			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P16949-20-unknown	FELILS...	20		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167599
P16949-20-	FELILS...	20			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16949-28-unknown	SKESVP...	28			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16949-28-unknown	SKESVP...	28			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16949-28-unknown	SKESVP...	28		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160326
P16949-28-	SKESVP...	28			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16949-28-	SKESVP...	28			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-28-	SKESVP...	28			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16949-28-	SKESVP...	28			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P16949-28-	SKESVP...	28			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16949-31-unknown	SVPEFP...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167601
P16949-31-	SVPEFP...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P16949-31-	SVPEFP...	31			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P16949-32-unknown	VPEFPL...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17398
P16949-32-unknown	VPEFPL...	32		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137754
P16949-42-unknown	KKDLSL...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165496
P16949-42-	KKDLSL...	42			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-42-	KKDLSL...	42			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16949-42-	KKDLSL...	42			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P16949-43-unknown	KDLSLE...	43		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165498
P16949-43-	KDLSLE...	43			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-65-unknown	EAEVLK...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18802
P16949-65-unknown	EAEVLK...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17400
P16949-65-unknown	EAEVLK...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140300
P16949-66-unknown	AEVLKQ...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18804
P16949-66-unknown	AEVLKQ...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17402
P16949-66-unknown	AEVLKQ...	66		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140367
P16949-81-unknown	EVLQKA...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164203
P16949-81-	EVLQKA...	81			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16949-81-	EVLQKA...	81			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-81-	EVLQKA...	81			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P16949-86-	AIEENN...	86			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16949-86-	AIEENN...	86			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P16949-86-	AIEENN...	86			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16949-86-unknown	AIEENN...	86		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168734
P16949-101-	LTHKME...	101			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16949-101-unknown	LTHKME...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169572
P16949-113-unknown	EAQMAA...	113			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P16949-125-unknown	EKDKHI...	125		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17404
P16949-127-	DKHIEE...	127			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P16949-136-	NKESKD...	136			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P16949-136-unknown	NKESKD...	136			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RSKESV	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17398
...RSKESV	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120753
...RRKSHE	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18802
...RRKSHE	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17400
...RRKSHE	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123422
...RKSHEA	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18804
...RKSHEA	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17402
...RKSHEA	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123490
...LERLRE	124	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17404
...LERLRE	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154664
...ETEAD	149	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ETEAD	149		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ETEAD	149		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ETEAD	149		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ETEAD	149		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	4	ASSD.\|.DIQV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	4	ASSD.\|.DIQV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	31	KESV.\|.VPEF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	64	KSHE.\|.EAEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	64	KSHE.\|.EAEV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	65	SHEA.\|.AEVL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	65	SHEA.\|.AEVL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	124	RLRE.\|.EKDK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)