P05388: 60S acidic ribosomal protein P0

General Information

Protein names	- 60S acidic ribosomal protein P0 - 60S ribosomal protein L10E - Large ribosomal subunit protein uL10 {ECO:0000303\|PubMed:24524803}
Gene names	RPLP0
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05388

18 N-termini

15 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK AVVLMGKNTM
        70         80         90        100        110        120
MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD MLLANKVPAA ARAGAIAPCE
       130        140        150        160        170        180
VTVPAQNTGL GPEKTSFFQA LGITTKISRG TIEILSDVQL IKTGDKVGAS EATLLNMLNI
       190        200        210        220        230        240
SPFSFGLVIQ QVFDNGSIYN PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS
       250        260        270        280        290        300
IINGYKRVLA LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA
       310
KEESEESDED MGFGLFD

Isoforms

- Isoform 2 of 60S acidic ribosomal protein P0

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 15 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P05388-1-unknown	MPREDR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05388-34-unknown	NVGSKQ...	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11045
P05388-100-unknown	DMLLAN...	100	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18480
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P05388-196-	GSIYNP...	196		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P05388-197-	SIYNPE...	197		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P05388-197-	SIYNPE...	197		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05388-197-	SIYNPE...	197		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P05388-197-	SIYNPE...	197		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P05388-198-	IYNPEV...	198		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P05388-205-unknown	DITEET...	205	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7205
P05388-256-unknown	DYTFPL...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18481
P05388-257-unknown	YTFPLA...	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11046
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P05388-278-	AAPVAA...	278		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P05388-278-unknown	AAPVAA...	278		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P05388-278-unknown	AAPVAA...	278		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P05388-279-unknown	APVAAA...	279	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18482
P05388-283-unknown	AATTAA...	283	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3491
P05388-285-unknown	TTAAPA...	285	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3492
P05388-285-unknown	TTAAPA...	285		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P05388-285-	TTAAPA...	285		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P05388-286-unknown	TAAPAA...	286	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3493
P05388-287-	AAPAAA...	287		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P05388-292-	AAAPAK...	292		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IVGADN	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11045
...LTEIRD	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18480
...VTVPAQ	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449765
...TGDKVG	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450121
...NPEVLD	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7205
...NGYKRV	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000448046
...LSVETD	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18481
...SVETDY	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11046
...PLAEKV	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000449854
...AFVAAA	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18482
...AAPVAA	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3491
...PVAAAT	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3492
...VAAATT	285	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3493
...AAAAPA	295	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447311
...FGLFD	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	33	GADN.\|.NVGS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	99	EIRD.\|.DMLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	204	EVLD.\|.DITE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	255	VETD.\|.DYTF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	256	ETDY.\|.YTFP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1B_HUMAN	278	VAAA.\|.APVA	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	282	PVAA.\|.AATT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	284	AAAT.\|.TTAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	285	AATT.\|.TAAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)