P49419: Alpha-aminoadipic semialdehyde dehydrogenase

General Information

Protein names	- Alpha-aminoadipic semialdehyde dehydrogenase - Alpha-AASA dehydrogenase - 1.2.1.31 - Aldehyde dehydrogenase family 7 member A1 - 1.2.1.3 - Antiquitin-1 - Betaine aldehyde dehydrogenase - 1.2.1.8 - Delta1-piperideine-6-carboxylate dehydrogenase - P6c dehydrogenase
Gene names	ALDH7A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49419

9 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Alpha-aminoadipic semialdehyde dehydrogenase - Isoform 3 of Alpha-aminoadipic semialdehyde dehydrogenase - Isoform 4 of Alpha-aminoadipic semialdehyde dehydrogenase - Isoform 4 of Alpha-aminoadipic semialdehyde dehydrogenase

Sequence View

        10         20         30         40         50         60
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG
        70         80         90        100        110        120
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA
       130        140        150        160        170        180
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE
       190        200        210        220        230        240
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED
       250        260        270        280        290        300
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN
       310        320        330        340        350        360
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG
       370        380        390        400        410        420
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD
       430        440        450        460        470        480
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI
       490        500        510        520        530
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ         10         20         30         40         50         60
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG
        70         80         90        100        110        120
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA
       130        140        150        160        170        180
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE
       190        200        210        220        230        240
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED
       250        260        270        280        290        300
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN
       310        320        330        340        350        360
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG
       370        380        390        400        410        420
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD
       430        440        450        460        470        480
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI
       490        500        510        520        530
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ         10         20         30         40         50         60
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG
        70         80         90        100        110        120
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA
       130        140        150        160        170        180
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE
       190        200        210        220        230        240
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED
       250        260        270        280        290        300
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN
       310        320        330        340        350        360
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG
       370        380        390        400        410        420
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD
       430        440        450        460        470        480
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI
       490        500        510        520        530
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ         10         20         30         40         50         60
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE NEGVYNGSWG
        70         80         90        100        110        120
GRGEVITTYC PANNEPIARV RQASVADYEE TVKKAREAWK IWADIPAPKR GEIVRQIGDA
       130        140        150        160        170        180
LREKIQVLGS LVSLEMGKIL VEGVGEVQEY VDICDYAVGL SRMIGGPILP SERSGHALIE
       190        200        210        220        230        240
QWNPVGLVGI ITAFNFPVAV YGWNNAIAMI CGNVCLWKGA PTTSLISVAV TKIIAKVLED
       250        260        270        280        290        300
NKLPGAICSL TCGGADIGTA MAKDERVNLL SFTGSTQVGK QVGLMVQERF GRSLLELGGN
       310        320        330        340        350        360
NAIIAFEDAD LSLVVPSALF AAVGTAGQRC TTARRLFIHE SIHDEVVNRL KKAYAQIRVG
       370        380        390        400        410        420
NPWDPNVLYG PLHTKQAVSM FLGAVEEAKK EGGTVVYGGK VMDRPGNYVE PTIVTGLGHD
       430        440        450        460        470        480
ASIAHTETFA PILYVFKFKN EEEVFAWNNE VKQGLSSSIF TKDLGRIFRW LGPKGSDCGI
       490        500        510        520        530
VNVNIPTSGA EIGGAFGGEK HTGGGRESGS DAWKQYMRRS TCTINYSKDL PLAQGIKFQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P49419-1-unknown	MWRLPR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66703
P49419-1-unknown	MWRLPR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103965
P49419-2-acetylation	WRLPRA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P49419-2-acetylation	WRLPRA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163286
P49419-2-acetylation	WRLPRA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163285
P49419-27-unknown	AFMSTL...	27		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49419-27-unknown	AFMSTL...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt114307
P49419-29-unknown	MSTLLI...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66702
P49419-29-unknown	MSTLLI...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103916
P49419-340-unknown	ESIHDE...	340		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5928
P49419-340-unknown	ESIHDE...	340		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7511
P49419-340-unknown	ESIHDE...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144627
P49419-340-unknown	ESIHDE...	340		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150149
P49419-341-unknown	SIHDEV...	341		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5931
P49419-341-unknown	SIHDEV...	341		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7514
P49419-341-unknown	SIHDEV...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144670
P49419-341-unknown	SIHDEV...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150175
P49419-364-unknown	DPNVLY...	364		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19158
P49419-364-unknown	DPNVLY...	364		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145612
P49419-364-unknown	DPNVLY...	364		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150646
P49419-380-unknown	MFLGAV...	380		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19161
P49419-380-unknown	MFLGAV...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146198
P49419-380-unknown	MFLGAV...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150992
P49419-381-unknown	FLGAVE...	381		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3810
P49419-381-unknown	FLGAVE...	381		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146229
P49419-381-unknown	FLGAVE...	381		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151020

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RLFIHE	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5928
...RLFIHE	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7511
...RLFIHE	339	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127894
...RLFIHE	339	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133542
...LFIHES	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5931
...LFIHES	340	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7514
...LFIHES	340	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127937
...LFIHES	340	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133569
...VGNPWD	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19158
...VGNPWD	363	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128910
...VGNPWD	363	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134044
...KQAVSM	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19161
...KQAVSM	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129500
...KQAVSM	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134395
...QAVSMF	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3810
...QAVSMF	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129533
...QAVSMF	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134423
...GIKFQ	539	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GIKFQ	539	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62321
...GIKFQ	539	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62322
...GIKFQ	539	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62320

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	339	FIHE.\|.ESIH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	339	FIHE.\|.ESIH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	340	IHES.\|.SIHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	340	IHES.\|.SIHD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	363	NPWD.\|.DPNV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	379	AVSM.\|.MFLG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	380	VSMF.\|.FLGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)