P43243: Matrin-3

General Information

Protein names	- Matrin-3
Gene names	MATR3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P43243

39 N-termini

14 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA RLASLMNLGM
        70         80         90        100        110        120
SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ HRGDADQASN ILASFGLSAR
       130        140        150        160        170        180
DLDELSRYPE DKITPENLPQ ILLQLKRRRT EEGPTLSYGR DGRSATREPP YRVPRDDWEE
       190        200        210        220        230        240
KRHFRRDSFD DRGPSLNPVL DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS
       250        260        270        280        290        300
HNYHKFDSEY ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
       310        320        330        340        350        360
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN PAPGILGPPP
       370        380        390        400        410        420
PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV HIMDFQRGKN LRYQLLQLVE
       430        440        450        460        470        480
PFGVISNHLI LNKINEAFIE MATTEDAQAA VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP
       490        500        510        520        530        540
EGKPDQKFDQ KQELGRVIHL SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME
       550        560        570        580        590        600
TREDAMAMVD HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
       610        620        630        640        650        660
GKESPSDKKS KTDGSQKTES STEGKEQEEK SGEDGEKDTK DDQTEQEPNM LLESEDELLV
       670        680        690        700        710        720
DEEEAAALLE SGSSVGDETD LANLGDVASD GKKEPSDKAV KKDGSASAAA KKKLKKVDKI
       730        740        750        760        770        780
EELDQENEAA LENGIKNEEN TEPGAESSEN ADDPNKDTSE NADGQSDENK DDYTIPDEYR
       790        800        810        820        830        840
IGPYQPNVPV GIDYVIPKTG FYCKLCSLFY TNEEVAKNTH CSSLPHYQKL KKFLNKLAEE

RRQKKET

Isoforms

- Isoform 2 of Matrin-3

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

39 N-termini - 14 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P43243-2-unknown	MSKSFQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43243-2-Acetylation	SKSFQQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P43243-2-Acetylation	SKSFQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P43243-2-Acetylation	SKSFQQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P43243-4-unknown	SFQQSS...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10081
P43243-4-unknown	SFQQSS...	4			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43243-4-	SFQQSS...	4			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-4-	SFQQSS...	4			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P43243-4-	SFQQSS...	4			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-30-unknown	AAATQS...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14129
P43243-30-	AAATQS...	30			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43243-31-	AATQSL...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43243-31-	AATQSL...	31			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-31-	AATQSL...	31			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43243-64-	LNQQGA...	64			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-72-	ALSSAS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-72-	ALSSAS...	72			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-75-unknown	SASTSS...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7464
P43243-99-	SQHRGD...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-137-unknown	NLPQIL...	137		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11519
P43243-188-unknown	SFDDRG...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1225
P43243-188-	SFDDRG...	188			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-188-	SFDDRG...	188			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-188-	SFDDRG...	188			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-188-	SFDDRG...	188			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43243-271-	GAPPSS...	271			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-271-	GAPPSS...	271			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-271-	GAPPSS...	271			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P43243-294-unknown	SICDLP...	294		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7465
P43243-294-unknown	SICDLP...	294		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5871
P43243-344-unknown	MLQQST...	344		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177353
P43243-344-	MLQQST...	344			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P43243-348-unknown	STNPAP...	348		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166644
P43243-348-	STNPAP...	348			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43243-348-	STNPAP...	348			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-348-	STNPAP...	348			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-348-	STNPAP...	348			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-348-	STNPAP...	348			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43243-357-unknown	GPPPPS...	357		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5872
P43243-357-unknown	GPPPPS...	357		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140592
P43243-364-unknown	HLGGPA...	364		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3799
P43243-364-unknown	HLGGPA...	364		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141073
P43243-365-unknown	LGGPAV...	365		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3801
P43243-365-unknown	LGGPAV...	365		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141141
P43243-374-unknown	GNLGAG...	374		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10082
P43243-374-unknown	GNLGAG...	374		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141629
P43243-453-unknown	YYTTTP...	453		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170144
P43243-453-	YYTTTP...	453			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-453-	YYTTTP...	453			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-453-	YYTTTP...	453			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43243-454-unknown	YTTTPA...	454		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170140
P43243-454-	YTTTPA...	454			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-461-unknown	VFGKPV...	461		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3803
P43243-461-unknown	VFGKPV...	461		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145648
P43243-548-unknown	MVDHCL...	548		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7466
P43243-548-unknown	MVDHCL...	548		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148794
P43243-681-unknown	LANLGD...	681		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3073
P43243-681-unknown	LANLGD...	681			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43243-681-unknown	LANLGD...	681		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151885
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P43243-681-	LANLGD...	681			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-682-	ANLGDV...	682			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P43243-682-unknown	ANLGDV...	682			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43243-682-unknown	ANLGDV...	682		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161792
P43243-734-unknown	GIKNEE...	734		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170147
P43243-734-	GIKNEE...	734			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-764-unknown	GQSDEN...	764			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P43243-764-unknown	GQSDEN...	764		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161794
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P43243-764-	GQSDEN...	764			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P43243-788-unknown	VPVGID...	788		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19105
P43243-788-unknown	VPVGID...	788		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153412

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GIGLLA	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14129
...HSALSS	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7464
...KITPEN	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11519
...HFRRDS	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1225
...YPHLCS	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7465
...YPHLCS	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5871
...APGILG	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5872
...APGILG	356	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123726
...PPPSFH	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3799
...PPPSFH	363	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124225
...PPSFHL	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3801
...PPSFHL	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124297
...AVGPRG	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10082
...AVGPRG	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124808
...TTPALV	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3803
...TTPALV	460	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128947
...EDAMAM	547	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7466
...EDAMAM	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132170
...GDETDL	680	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3073
...GDETDL	680	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135290
...PYQPNV	787	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19105
...PYQPNV	787	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136835
...QKKET	847	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKKET	847	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76105

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	3	MSKS.\|.SFQQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	29	GLLA.\|.AAAT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	74	ALSS.\|.SAST	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	136	TPEN.\|.NLPQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_HUMAN	187	RRDS.\|.SFDD	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CATS_HUMAN	293	HLCS.\|.SICD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	293	HLCS.\|.SICD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	356	GILG.\|.GPPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	363	PSFH.\|.HLGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	364	SFHL.\|.LGGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	373	GPRG.\|.GNLG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATB_HUMAN	460	PALV.\|.VFGK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	547	AMAM.\|.MVDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP8_HUMAN	680	ETDL.\|.LANL	inferred from experiment	unknown	MEROPS	Liu R	Valencia CA et al.:Matrin 3 is a Ca2+/calmodulin-b... (C14.003)	17658460,
MEP1B_HUMAN	787	QPNV.\|.VPVG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)