O95793: Double-stranded RNA-binding protein Staufen homolog 1

General Information

Protein names	- Double-stranded RNA-binding protein Staufen homolog 1
Gene names	STAU1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95793

12 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Double-stranded RNA-binding protein Staufen homolog 1 - Isoform 3 of Double-stranded RNA-binding protein Staufen homolog 1

Sequence View

        10         20         30         40         50         60
MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP IQNSALPSAS
        70         80         90        100        110        120
ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ STYNYNMRGG AYPPRYFYPF
       130        140        150        160        170        180
PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH DAAAKALRIL QNEPLPERLE VNGRESEEEN
       190        200        210        220        230        240
LNKSEISQVF EIALKRNLPV NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN
       250        260        270        280        290        300
AAIAVLEELK KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE
       310        320        330        340        350        360
KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE ILGFKVPQAQ
       370        380        390        400        410        420
PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE DEFRMPYLSH QQLPAGILPM
       430        440        450        460        470        480
VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKNNISSGH
       490        500        510        520        530        540
VPHGPLTRPS EQLDYLSRVQ GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES
       550        560        570
CHDMAALNIL KLLSELDQQS TEMPRTGNGP MSVCGRC         10         20         30         40         50         60
MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP IQNSALPSAS
        70         80         90        100        110        120
ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ STYNYNMRGG AYPPRYFYPF
       130        140        150        160        170        180
PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH DAAAKALRIL QNEPLPERLE VNGRESEEEN
       190        200        210        220        230        240
LNKSEISQVF EIALKRNLPV NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN
       250        260        270        280        290        300
AAIAVLEELK KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE
       310        320        330        340        350        360
KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE ILGFKVPQAQ
       370        380        390        400        410        420
PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE DEFRMPYLSH QQLPAGILPM
       430        440        450        460        470        480
VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKNNISSGH
       490        500        510        520        530        540
VPHGPLTRPS EQLDYLSRVQ GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES
       550        560        570
CHDMAALNIL KLLSELDQQS TEMPRTGNGP MSVCGRC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95793-2-unknown	MSQVQV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95793-2-Acetylation	SQVQVQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95793-82-unknown	MKLGKK...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90881
O95793-82-unknown	MKLGKK...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90882
O95793-132-unknown	SVGGQQ...	132		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13904
O95793-132-unknown	SVGGQQ...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139267
O95793-132-unknown	SVGGQQ...	132		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139268
O95793-159-unknown	ILQNEP...	159		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9924
O95793-159-unknown	ILQNEP...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141201
O95793-159-unknown	ILQNEP...	159		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141202
O95793-177-unknown	EEENLN...	177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16976
O95793-177-unknown	EEENLN...	177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18331
O95793-177-unknown	EEENLN...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142166
O95793-177-unknown	EEENLN...	177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142167
O95793-356-unknown	VPQAQP...	356		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170016
O95793-356-unknown	VPQAQP...	356		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170015
O95793-356-	VPQAQP...	356			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O95793-359-unknown	AQPTKP...	359		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7079
O95793-359-unknown	AQPTKP...	359		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5295
O95793-359-unknown	AQPTKP...	359		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149294
O95793-359-unknown	AQPTKP...	359		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149452
O95793-430-unknown	VSQGHH...	430		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168183
O95793-430-unknown	VSQGHH...	430		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168182
O95793-430-	VSQGHH...	430			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O95793-430-	VSQGHH...	430			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O95793-488-unknown	RPSEQL...	488		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5298
O95793-488-unknown	RPSEQL...	488		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152117
O95793-488-unknown	RPSEQL...	488		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152210

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YQVELS	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13904
...YQVELS	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122342
...YQVELS	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122343
...AKALRI	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9924
...AKALRI	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124361
...AKALRI	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124362
...NGRESE	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16976
...NGRESE	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18331
...NGRESE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125353
...NGRESE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125354
...FKVPQA	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7079
...FKVPQA	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5295
...FKVPQA	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132679
...FKVPQA	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132837
...HGPLTR	487	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5298
...HGPLTR	487	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135526
...HGPLTR	487	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135620
...VCGRC	577	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VCGRC	577	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86499
...VCGRC	577	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86500

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	131	VELS.\|.SVGG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	158	ALRI.\|.ILQN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	176	RESE.\|.EEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	176	RESE.\|.EEEN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	358	VPQA.\|.AQPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	358	VPQA.\|.AQPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	487	PLTR.\|.RPSE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)