P09683: Secretin {ECO:0000303|PubMed:11060443}

General Information

Protein names	- Secretin {ECO:0000303\|PubMed:11060443}
Gene names	SCT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09683

17 N-termini

16 C-termini

17 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ
        70         80         90        100        110        120
DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL PPGPMVSEPA GAAAEGTLRP

R

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 16 C-termini - 17 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P09683-19-unknown	RPAPPR...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P09683-30-unknown	DGTFTS...	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18631
P09683-31-unknown	GTFTSE...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17247
P09683-31-unknown	GTFTSE...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18632
P09683-32-unknown	TFTSEL...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17248
P09683-33-unknown	FTSELS...	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17249
P09683-34-unknown	TSELSR...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17250
P09683-35-unknown	SELSRL...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17251
P09683-39-unknown	RLREGA...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17252
P09683-40-unknown	LREGAR...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17253
P09683-42-unknown	EGARLQ...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17254
P09683-43-unknown	GARLQR...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17255
P09683-44-unknown	ARLQRL...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17256
P09683-45-unknown	RLQRLL...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17257
P09683-46-unknown	LQRLLQ...	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17258
P09683-48-unknown	RLLQGL...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17259
P09683-49-unknown	LLQGLV...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17260
P09683-52-unknown	GLVGKR...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17261

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARRHSD	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18631
...RRHSDG	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17247
...RRHSDG	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18632
...RHSDGT	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17248
...HSDGTF	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17249
...SDGTFT	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17250
...DGTFTS	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17251
...TSELSR	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17252
...SELSRL	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17253
...LSRLRE	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17254
...SRLREG	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17255
...RLREGA	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17256
...LREGAR	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17257
...REGARL	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17258
...GARLQR	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17259
...ARLQRL	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17260
...QRLLQG	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17261

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	29	RHSD.\|.DGTF	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	30	HSDG.\|.GTFT	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1B_HUMAN	30	HSDG.\|.GTFT	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	31	SDGT.\|.TFTS	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	32	DGTF.\|.FTSE	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	33	GTFT.\|.TSEL	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	34	TFTS.\|.SELS	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	38	ELSR.\|.RLRE	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	39	LSRL.\|.LREG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	41	RLRE.\|.EGAR	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	42	LREG.\|.GARL	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	43	REGA.\|.ARLQ	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	44	EGAR.\|.RLQR	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	45	GARL.\|.LQRL	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	47	RLQR.\|.RLLQ	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	48	LQRL.\|.LLQG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	51	LLQG.\|.GLVG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)