TopFIND 4.0

P11021: Endoplasmic reticulum chaperone BiP {ECO:0000305}

General Information

Protein names
- Endoplasmic reticulum chaperone BiP {ECO:0000305}
- 3.6.4.10 {ECO:0000269|PubMed:26655470}
- 78 kDa glucose-regulated protein {ECO:0000303|PubMed:2840249}
- GRP-78 {ECO:0000303|PubMed:2840249}
- Binding-immunoglobulin protein {ECO:0000303|Ref.4}
- BiP {ECO:0000303|Ref.4}
- Heat shock protein 70 family protein 5 {ECO:0000305}
- HSP70 family protein 5 {ECO:0000305}
- Heat shock protein family A member 5 {ECO:0000312|HGNC:HGNC:5238}
- Immunoglobulin heavy chain-binding protein {ECO:0000303|Ref.4}
Gene names HSPA5
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID P11021

14

N-termini

6

C-termini

7

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 
        70         80         90        100        110        120 
ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 
       130        140        150        160        170        180 
EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 
       190        200        210        220        230        240 
RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 
       250        260        270        280        290        300 
VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 
       310        320        330        340        350        360 
SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 
       370        380        390        400        410        420 
LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 
       430        440        450        460        470        480 
PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 
       490        500        510        520        530        540 
TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 
       550        560        570        580        590        600 
MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 
       610        620        630        640        650    
KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

14 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)