Q9NYF8: Bcl-2-associated transcription factor 1

General Information

Protein names	- Bcl-2-associated transcription factor 1 - Btf - BCLAF1 and THRAP3 family member 1
Gene names	BCLAF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NYF8

22 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Bcl-2-associated transcription factor 1 - Isoform 3 of Bcl-2-associated transcription factor 1 - Isoform 4 of Bcl-2-associated transcription factor 1

Sequence View

        10         20         30         40         50         60
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD RMYSRDYRRD
        70         80         90        100        110        120
YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR HSRSPRRGRS RSRSPKRRSV
       130        140        150        160        170        180
SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY SKSPVSKRRG SQEKQTKKAE GEPQEESPLK
       190        200        210        220        230        240
SKSQEEPKDT FEHDPSESID EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS
       250        260        270        280        290        300
SCSDAPMLST VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS
       310        320        330        340        350        360
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKRF TDEESRVFLL DRGNTRDKEA
       370        380        390        400        410        420
SKEKGSEKGR AEGEWEDQEA LDYFSDKESG KQKFNDSEGD DTEETEDYRQ FRKSVLADQG
       430        440        450        460        470        480
KSFATASHRN TEEEGLKYKS KVSLKGNRES DGFREEKNYK LKETGYVVER PSTTKDKHKE
       490        500        510        520        530        540
EDKNSERITV KKETQSPEQV KSEKLKDLFD YSPPLHKNLD AREKSTFREE SPLRIKMIAS
       550        560        570        580        590        600
DSHRPEVKLK MAPVPLDDSN RPASLTKDRL LASTLVHSVK KEQEFRSIFD HIKLPQASKS
       610        620        630        640        650        660
TSESFIQHIV SLVHHVKEQY FKSAAMTLNE RFTSYQKATE EHSTRQKSPE IHRRIDISPS
       670        680        690        700        710        720
TLRKHTRLAG EERVFKEENQ KGDKKLRCDS ADLRHDIDRR RKERSKERGD SKGSRESSGS
       730        740        750        760        770        780
RKQEKTPKDY KEYKSYKDDS KHKREQDHSR SSSSSASPSS PSSREEKESK KEREEEFKTH
       790        800        810        820        830        840
HEMKEYSGFA GVSRPRGTFF RIRGRGRARG VFAGTNTGPN NSNTTFQKRP KEEEWDPEYT
       850        860        870        880        890        900
PKSKKYFLHD DRDDGVDYWA KRGRGRGTFQ RGRGRFNFKK SGSSPKWTHD KYQGDGIVED
       910        920
EEETMENNEE KKDRRKEEKE         10         20         30         40         50         60
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD RMYSRDYRRD
        70         80         90        100        110        120
YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR HSRSPRRGRS RSRSPKRRSV
       130        140        150        160        170        180
SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY SKSPVSKRRG SQEKQTKKAE GEPQEESPLK
       190        200        210        220        230        240
SKSQEEPKDT FEHDPSESID EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS
       250        260        270        280        290        300
SCSDAPMLST VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS
       310        320        330        340        350        360
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKRF TDEESRVFLL DRGNTRDKEA
       370        380        390        400        410        420
SKEKGSEKGR AEGEWEDQEA LDYFSDKESG KQKFNDSEGD DTEETEDYRQ FRKSVLADQG
       430        440        450        460        470        480
KSFATASHRN TEEEGLKYKS KVSLKGNRES DGFREEKNYK LKETGYVVER PSTTKDKHKE
       490        500        510        520        530        540
EDKNSERITV KKETQSPEQV KSEKLKDLFD YSPPLHKNLD AREKSTFREE SPLRIKMIAS
       550        560        570        580        590        600
DSHRPEVKLK MAPVPLDDSN RPASLTKDRL LASTLVHSVK KEQEFRSIFD HIKLPQASKS
       610        620        630        640        650        660
TSESFIQHIV SLVHHVKEQY FKSAAMTLNE RFTSYQKATE EHSTRQKSPE IHRRIDISPS
       670        680        690        700        710        720
TLRKHTRLAG EERVFKEENQ KGDKKLRCDS ADLRHDIDRR RKERSKERGD SKGSRESSGS
       730        740        750        760        770        780
RKQEKTPKDY KEYKSYKDDS KHKREQDHSR SSSSSASPSS PSSREEKESK KEREEEFKTH
       790        800        810        820        830        840
HEMKEYSGFA GVSRPRGTFF RIRGRGRARG VFAGTNTGPN NSNTTFQKRP KEEEWDPEYT
       850        860        870        880        890        900
PKSKKYFLHD DRDDGVDYWA KRGRGRGTFQ RGRGRFNFKK SGSSPKWTHD KYQGDGIVED
       910        920
EEETMENNEE KKDRRKEEKE         10         20         30         40         50         60
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD RMYSRDYRRD
        70         80         90        100        110        120
YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR HSRSPRRGRS RSRSPKRRSV
       130        140        150        160        170        180
SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY SKSPVSKRRG SQEKQTKKAE GEPQEESPLK
       190        200        210        220        230        240
SKSQEEPKDT FEHDPSESID EFNKSSATSG DIWPGLSAYD NSPRSPHSPS PIATPPSQSS
       250        260        270        280        290        300
SCSDAPMLST VHSAKNTPSQ HSHSIQHSPE RSGSGSVGNG SSRYSPSQNS PIHHIPSRRS
       310        320        330        340        350        360
PAKTIAPQNA PRDESRGRSS FYPDGGDQET AKTGKFLKRF TDEESRVFLL DRGNTRDKEA
       370        380        390        400        410        420
SKEKGSEKGR AEGEWEDQEA LDYFSDKESG KQKFNDSEGD DTEETEDYRQ FRKSVLADQG
       430        440        450        460        470        480
KSFATASHRN TEEEGLKYKS KVSLKGNRES DGFREEKNYK LKETGYVVER PSTTKDKHKE
       490        500        510        520        530        540
EDKNSERITV KKETQSPEQV KSEKLKDLFD YSPPLHKNLD AREKSTFREE SPLRIKMIAS
       550        560        570        580        590        600
DSHRPEVKLK MAPVPLDDSN RPASLTKDRL LASTLVHSVK KEQEFRSIFD HIKLPQASKS
       610        620        630        640        650        660
TSESFIQHIV SLVHHVKEQY FKSAAMTLNE RFTSYQKATE EHSTRQKSPE IHRRIDISPS
       670        680        690        700        710        720
TLRKHTRLAG EERVFKEENQ KGDKKLRCDS ADLRHDIDRR RKERSKERGD SKGSRESSGS
       730        740        750        760        770        780
RKQEKTPKDY KEYKSYKDDS KHKREQDHSR SSSSSASPSS PSSREEKESK KEREEEFKTH
       790        800        810        820        830        840
HEMKEYSGFA GVSRPRGTFF RIRGRGRARG VFAGTNTGPN NSNTTFQKRP KEEEWDPEYT
       850        860        870        880        890        900
PKSKKYFLHD DRDDGVDYWA KRGRGRGTFQ RGRGRFNFKK SGSSPKWTHD KYQGDGIVED
       910        920
EEETMENNEE KKDRRKEEKE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

22 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NYF8-1-unknown	MGRSNS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NYF8-1-unknown	MGRSNS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68336
Q9NYF8-1-unknown	MGRSNS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68337
Q9NYF8-1-unknown	MGRSNS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68338
Q9NYF8-40-unknown	SRTYSR...	40	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9NYF8-40-unknown	SRTYSR...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195881
Q9NYF8-40-unknown	SRTYSR...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195882
Q9NYF8-40-unknown	SRTYSR...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195880
Q9NYF8-383-unknown	YFSDKE...	383	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13449
Q9NYF8-383-unknown	YFSDKE...	383	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151650
Q9NYF8-383-unknown	YFSDKE...	383	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151651
Q9NYF8-383-	YFSDKE...	383		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NYF8-414-	SVLADQ...	414		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYF8-414-	SVLADQ...	414		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NYF8-414-unknown	SVLADQ...	414		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NYF8-414-unknown	SVLADQ...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159463
Q9NYF8-414-unknown	SVLADQ...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159464
Q9NYF8-417-unknown	ADQGKS...	417	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15076
Q9NYF8-417-unknown	ADQGKS...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152259
Q9NYF8-417-unknown	ADQGKS...	417	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152260
Q9NYF8-418-unknown	DQGKSF...	418	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19821
Q9NYF8-418-unknown	DQGKSF...	418	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152263
Q9NYF8-418-unknown	DQGKSF...	418	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152265
Q9NYF8-419-unknown	QGKSFA...	419	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13452
Q9NYF8-419-unknown	QGKSFA...	419	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152282
Q9NYF8-419-unknown	QGKSFA...	419	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152283
Q9NYF8-461-	LKETGY...	461		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYF8-461-unknown	LKETGY...	461	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169554
Q9NYF8-461-unknown	LKETGY...	461	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169555
Q9NYF8-492-unknown	KETQSP...	492	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166039
Q9NYF8-492-unknown	KETQSP...	492	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166040
Q9NYF8-492-	KETQSP...	492		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NYF8-537-unknown	MIASDS...	537		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NYF8-537-unknown	MIASDS...	537	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161312
Q9NYF8-537-unknown	MIASDS...	537	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161313
Q9NYF8-537-unknown	MIASDS...	537	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161314
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NYF8-537-	MIASDS...	537		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NYF8-542-unknown	SHRPEV...	542	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13455
Q9NYF8-542-unknown	SHRPEV...	542	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151390
Q9NYF8-542-unknown	SHRPEV...	542	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153868
Q9NYF8-542-unknown	SHRPEV...	542	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153869
Q9NYF8-549-unknown	LKMAPV...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169550
Q9NYF8-549-unknown	LKMAPV...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169551
Q9NYF8-549-unknown	LKMAPV...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169552
Q9NYF8-549-	LKMAPV...	549		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9NYF8-551-	MAPVPL...	551		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NYF8-551-unknown	MAPVPL...	551		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NYF8-551-unknown	MAPVPL...	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159459
Q9NYF8-551-unknown	MAPVPL...	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159460
Q9NYF8-551-unknown	MAPVPL...	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159461
Q9NYF8-765-unknown	EEKESK...	765	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10570
Q9NYF8-765-unknown	EEKESK...	765	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154487
Q9NYF8-765-unknown	EEKESK...	765	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156324
Q9NYF8-765-unknown	EEKESK...	765	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156325
Q9NYF8-896-unknown	GIVEDE...	896	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13459
Q9NYF8-896-unknown	GIVEDE...	896	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3227
Q9NYF8-896-unknown	GIVEDE...	896	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156091
Q9NYF8-896-unknown	GIVEDE...	896	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156674
Q9NYF8-896-unknown	GIVEDE...	896	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156842

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QEALDY	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13449
...QEALDY	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135052
...QEALDY	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135053
...RKSVLA	416	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15076
...RKSVLA	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135669
...RKSVLA	416	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135670
...KSVLAD	417	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19821
...KSVLAD	417	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135673
...KSVLAD	417	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135675
...SVLADQ	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13452
...SVLADQ	418	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135692
...SVLADQ	418	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135693
...MIASDS	541	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13455
...MIASDS	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134792
...MIASDS	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137290
...MIASDS	541	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137291
...SPSSRE	764	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10570
...SPSSRE	764	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137909
...SPSSRE	764	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139796
...SPSSRE	764	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139797
...KYQGDG	895	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13459
...KYQGDG	895	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3227
...KYQGDG	895	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139554
...KYQGDG	895	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140160
...KYQGDG	895	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140338
...KEEKE	920	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KEEKE	920	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63956
...KEEKE	920	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63955
...KEEKE	920	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63954

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	382	ALDY.\|.YFSD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	416	SVLA.\|.ADQG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1B_HUMAN	417	VLAD.\|.DQGK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	418	LADQ.\|.QGKS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	541	ASDS.\|.SHRP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	764	SSRE.\|.EEKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	895	QGDG.\|.GIVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASPE_HUMAN	895	QGDG.\|.GIVE	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> BCLF1_HUMAN @895

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)