Q14444: Caprin-1

General Information

Protein names	- Caprin-1 - Cell cycle-associated protein 1 - Cytoplasmic activation- and proliferation-associated protein 1 - GPI-anchored membrane protein 1 - GPI-anchored protein p137 - GPI-p137 - p137GPI - Membrane component chromosome 11 surface marker 1 - RNA granule protein 105
Gene names	CAPRIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14444

44 N-termini

9 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ TEAMKQILGV
        70         80         90        100        110        120
IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ EVTNNLEFAK ELQRSFMALS
       130        140        150        160        170        180
QDIQKTIKKT ARREQLMREE AEQKRLKTVL ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE
       190        200        210        220        230        240
EELSLLDEFY KLVDPERDMS LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV
       250        260        270        280        290        300
FQSNYFDSTH NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM
       310        320        330        340        350        360
AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA DPLVRRQRVQ
       370        380        390        400        410        420
DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN MDMPQLVCPP VHSESRLAQP
       430        440        450        460        470        480
NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA
       490        500        510        520        530        540
SSSLPAASQP QVFQAGTSKP LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ
       550        560        570        580        590        600
YQASYNQSFS SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS
       610        620        630        640        650        660
NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG YTQSQFSAPR
       670        680        690        700
DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM PQMNTQQVN

Isoforms

- Isoform 2 of Caprin-1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

44 N-termini - 9 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14444-1-unknown	MPSATS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69268
Q14444-2-unknown	MPSATS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14444-2-Acetylation	PSATSH...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14444-2-Acetylation	PSATSH...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110634
Q14444-31-unknown	GAGAAA...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4044
Q14444-31-unknown	GAGAAA...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137647
Q14444-45-unknown	GTGAVQ...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4046
Q14444-45-unknown	GTGAVQ...	45			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14444-45-unknown	GTGAVQ...	45		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138780
Q14444-95-unknown	AVSKYQ...	95		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166169
Q14444-95-unknown	AVSKYQ...	95		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14444-95-	AVSKYQ...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-95-	AVSKYQ...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-95-	AVSKYQ...	95			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-95-	AVSKYQ...	95			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14444-95-	AVSKYQ...	95			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14444-98-	KYQEVT...	98			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-98-	KYQEVT...	98			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14444-98-unknown	KYQEVT...	98		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166185
Q14444-291-unknown	STEYVN...	291		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173048
Q14444-291-	STEYVN...	291			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-326-	SLQQQP...	326			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-326-	SLQQQP...	326			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-326-	SLQQQP...	326			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-326-unknown	SLQQQP...	326		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166173
Q14444-333-	AASPSV...	333			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-333-	AASPSV...	333			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-333-unknown	AASPSV...	333		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166183
Q14444-334-	ASPSVP...	334			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-334-	ASPSVP...	334			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-334-	ASPSVP...	334			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-334-	ASPSVP...	334			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14444-334-unknown	ASPSVP...	334		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166171
Q14444-337-unknown	SVPEPH...	337		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173044
Q14444-337-	SVPEPH...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-376-unknown	SMLDFE...	376		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12229
Q14444-376-unknown	SMLDFE...	376		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151544
Q14444-445-	SQPLYQ...	445			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-445-unknown	SQPLYQ...	445		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174875
Q14444-450-unknown	QPSHAT...	450		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19515
Q14444-450-unknown	QPSHAT...	450		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152789
Q14444-503-unknown	SSGINV...	503		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4048
Q14444-503-unknown	SSGINV...	503		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153445
Q14444-523-	NAPVPP...	523			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-523-	NAPVPP...	523			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-523-	NAPVPP...	523			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-523-	NAPVPP...	523			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14444-523-	NAPVPP...	523			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14444-523-unknown	NAPVPP...	523		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166175
Q14444-544-	SYNQSF...	544			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-544-unknown	SYNQSF...	544		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166189
Q14444-568-	TVVGTY...	568			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-568-	TVVGTY...	568			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14444-568-unknown	TVVGTY...	568		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166179
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14444-572-	TYHGSP...	572			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14444-572-unknown	TYHGSP...	572		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166177
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14444-575-	GSPDQS...	575			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14444-575-unknown	GSPDQS...	575		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166181
Q14444-576-	SPDQSH...	576			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14444-576-unknown	SPDQSH...	576		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170003
Q14444-583-unknown	VTGNHQ...	583		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4050
Q14444-583-unknown	VTGNHQ...	583		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154374
Q14444-586-unknown	NHQQPP...	586		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173042
Q14444-586-	NHQQPP...	586			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-587-unknown	HQQPPQ...	587		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173046
Q14444-587-	HQQPPQ...	587			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14444-588-unknown	QQPPQQ...	588		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166187
Q14444-588-	QQPPQQ...	588			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14444-669-unknown	GYQQNF...	669		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1298
Q14444-669-unknown	GYQQNF...	669		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155524

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SEAAAG	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4044
...SEAAAG	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120643
...QHPATG	44	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4046
...QHPATG	44	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt121835
...NFIQDS	375	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12229
...NFIQDS	375	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134949
...SQPLYQ	449	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19515
...SQPLYQ	449	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136212
...SKPLHS	502	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4048
...SKPLHS	502	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136868
...DQSHQV	582	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4050
...DQSHQV	582	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137795
...GYQRDG	668	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1298
...GYQRDG	668	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138962
...TQQVN	709		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TQQVN	709		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...TQQVN	709	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TQQVN	709		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TQQVN	709		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	30	AAAG.\|.GAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	44	PATG.\|.GTGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	375	IQDS.\|.SMLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
MEP1B_HUMAN	449	PLYQ.\|.QPSH	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	502	PLHS.\|.SSGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	582	SHQV.\|.VTGN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP1_HUMAN	668	QRDG.\|.GYQQ	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)