P38646: Stress-70 protein, mitochondrial

General Information

Protein names	- Stress-70 protein, mitochondrial - 75 kDa glucose-regulated protein - GRP-75 - Heat shock 70 kDa protein 9 - Mortalin - MOT - Peptide-binding protein 74 - PBP74
Gene names	HSPA9
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P38646

13 N-termini

11 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MISASRAAAA RLVGAAASRG PTAARHQDSW NGLSHEAFRL VSRRDYASEA IKGAVVGIDL
        70         80         90        100        110        120
GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL VGMPAKRQAV TNPNNTFYAT
       130        140        150        160        170        180
KRLIGRRYDD PEVQKDIKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN
       190        200        210        220        230        240
YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI
       250        260        270        280        290        300
AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK
       310        320        330        340        350        360
DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDSSGPK HLNMKLTRAQ FEGIVTDLIR
       370        380        390        400        410        420
RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG
       430        440        450        460        470        480
AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT
       490        500        510        520        530        540
QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG
       550        560        570        580        590        600
REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK
       610        620        630        640        650        660
DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE
       670
GSGSSGTGEQ KEDQKEEKQ

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 11 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P38646-47-unknown	ASEAIK...	47	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P38646-47-	ASEAIK...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P38646-47-	ASEAIK...	47		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P38646-47-	ASEAIK...	47		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P38646-47-	ASEAIK...	47		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P38646-70-unknown	MEGKQA...	70	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425598
P38646-70-unknown	MEGKQA...	70	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423098
P38646-150-unknown	GDAWVE...	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19089
P38646-150-unknown	GDAWVE...	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17625
P38646-151-unknown	DAWVEA...	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19090
P38646-152-unknown	AWVEAH...	152	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17626
P38646-266-	STNGDT...	266		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P38646-266-	STNGDT...	266		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P38646-269-	GDTFLG...	269		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P38646-275-unknown	GEDFDQ...	275	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7451
P38646-352-unknown	EGIVTD...	352	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17627
P38646-550-unknown	SGGLSK...	550	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17628
P38646-584-	MAEGII...	584		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P38646-584-	MAEGII...	584		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P38646-586-unknown	EGIIHD...	586	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7452

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RYDDPE	131	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423098
...VRASNG	149	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19089
...VRASNG	149	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17625
...RASNGD	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19090
...ASNGDA	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17626
...LYSPSQ	164	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425598
...DTFLGG	274	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7451
...TRAQFE	351	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17627
...IVIQSS	549	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17628
...AVNMAE	585	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7452
...KEEKQ	679	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KEEKQ	679		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEEKQ	679		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KEEKQ	679		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEEKQ	679		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	149	ASNG.\|.GDAW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	149	ASNG.\|.GDAW	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	150	SNGD.\|.DAWV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	151	NGDA.\|.AWVE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	274	FLGG.\|.GEDF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	351	AQFE.\|.EGIV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	549	IQSS.\|.SGGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	585	NMAE.\|.EGII	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)